Results 31 to 40 of about 559,832 (299)

Applications of artificial intelligence in early childhood health management: a systematic review from fetal to pediatric periods

Frontiers in Pediatrics
BackgroundThe integration of artificial intelligence (AI) into early childhood health management has expanded rapidly, with applications spanning the fetal, neonatal, and pediatric periods. While numerous studies report promising results, a comprehensive
Qingsong Wang, Jun Yin, Xiaomeng Zhang, Huimin Ou, Fuyan Li, Yundong Zhang, Weiyi Wan, Caiyu Guo, Yongyu Cao, Tongyong Luo, Xianmin Wang   +10 more
doaj   +1 more source

Trophectoderm biopsy of blastocysts for a preimplantation genetic test does not affect serum β-hCG levels in early pregnancy: a study using propensity score matching

Journal of Ovarian Research, 2021
Background Although preimplantation genetic test (PGT) has been used worldwide, few studies investigated the effect of trophectoderm biopsy of blastocysts on early embryo development.
Yixuan Wu, Ying Ying, Mingzhu Cao, Jianqiao Liu, Haiying Liu   +4 more
doaj   +1 more source

Fetal programming and future disease [PDF]

Revista do Hospital das Clínicas, 2004
Recent epidemiological studies have demonstrated a close relationship between low birth weight and a high predisposition to arterial hypertension, hyperlipidemia and non-insulin-dependent diabetes in adulthood. These findings may coexist as Syndrome X, more recently named as Metabolic Syndrome, and understood as precursory of coronary heart disease and
openaire   +3 more sources

Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly

NeuroImage: Clinical, 2018
Neuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of maldevelopment. In this work, brain
Oualid M. Benkarim, Nadine Hahner, Gemma Piella, Eduard Gratacos, Miguel Angel González Ballester, Elisenda Eixarch, Gerard Sanroma   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Fetal microchimeric cells in blood of women with an autoimmune thyroid disease. [PDF]

PLoS ONE, 2011
ContextHashimoto's thyroiditis (HT) and Graves' disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition.
Trees Lepez, Mado Vandewoestyne, Shahid Hussain, Filip Van Nieuwerburgh, Kris Poppe, Brigitte Velkeniers, Jean-Marc Kaufman, Dieter Deforce   +7 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source