Results 41 to 50 of about 10,169,242 (292)

What is fetal programming?: a lifetime health is under the control of in utero health

Obstetrics & Gynecology Science, 2017
The “Barker hypothesis” postulates that a number of organ structures and associated functions undergo programming during embryonic and fetal life, which determines the set point of physiological and metabolic responses that carry into adulthood.
E. Kwon, Y. J. Kim
semanticscholar   +1 more source

Oxidative stress in pediatric diseases associated with the origin of life and growth and development

Frontiers in Cell and Developmental Biology
The presence of oxidative stress and an imbalance in antioxidant mechanisms have been demonstrated in numerous diseases. Furthermore, mounting evidence suggests that the occurrence, progression, and prognosis of certain pediatric diseases linked to the ...
Bo Zheng, Jianhua Fu
doaj   +1 more source

Fetal gene therapy for neurodegenerative disease of infants

Nature Network Boston, 2018
For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. To explore this, we studied neuronopathic Gaucher disease (nGD), caused by mutations in GBA.
G. Massaro, C. Mattar, A. Wong, E. Sirka, S. Buckley, B. Herbert, S. Karlsson, D. Perocheau, D. Burke, S. Heales, A. Richard-Londt, S. Brandner, Mylene Huebecker, D. Priestman, F. Platt, K. Mills, A. Biswas, J. Cooper, J. Chan, Seng H. Cheng, S. Waddington, A. Rahim   +21 more
semanticscholar   +1 more source

Trophectoderm biopsy of blastocysts for a preimplantation genetic test does not affect serum β-hCG levels in early pregnancy: a study using propensity score matching

Journal of Ovarian Research, 2021
Background Although preimplantation genetic test (PGT) has been used worldwide, few studies investigated the effect of trophectoderm biopsy of blastocysts on early embryo development.
Yixuan Wu, Ying Ying, Mingzhu Cao, Jianqiao Liu, Haiying Liu   +4 more
doaj   +1 more source

Cortical folding alterations in fetuses with isolated non-severe ventriculomegaly

NeuroImage: Clinical, 2018
Neuroimaging of brain diseases plays a crucial role in understanding brain abnormalities and early diagnosis. Of great importance is the study of brain abnormalities in utero and the assessment of deviations in case of maldevelopment. In this work, brain
Oualid M. Benkarim, Nadine Hahner, Gemma Piella, Eduard Gratacos, Miguel Angel González Ballester, Elisenda Eixarch, Gerard Sanroma   +6 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Placental Responses to Changes in the Maternal Environment Determine Fetal Growth

Frontiers in Physiology, 2016
Placental responses to maternal perturbations are complex and remain poorly understood. Altered maternal environment during pregnancy such as hypoxia, stress, obesity, diabetes, toxins, altered nutrition, inflammation, and reduced utero-placental blood ...
K. G. Dimasuay, Philippe Boeuf, T. Powell, T. Jansson   +3 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source