Results 71 to 80 of about 9,953,634 (331)

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors

Genome Medicine, 2015
BackgroundDNA methylation is an epigenetic modification that plays an important role during mammalian development. Around birth in humans, the main site of red blood cell production moves from the fetal liver to the bone marrow.
S. Lessard, M. Beaudoin, K. Benkirane, G. Lettre   +3 more
semanticscholar   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

The Lower Limb Movements of the Fetus in Uterus: A Narrative Review

Applied Bionics and Biomechanics, 2023
The fetus movements play an important role in fetal well-being. With the continuous advancement of real-time scanning machines, it is feasible to observe the fetus movement in detail.
Xiaoxue Zhao, Jan Awrejcewicz, Jianpeng Li, Yuhuan He, Yaodong Gu   +4 more
doaj   +1 more source

Fetal Health State Detection Using Interval Type-2 Fuzzy Neural Networks

Diagnostics, 2023
Diagnosis of fetal health is a difficult process that depends on various input factors. Depending on the values or the interval of values of these input symptoms, the detection of fetal health status is implemented. Sometimes it is difficult to determine
Rahib Abiyev, John Bush Idoko, Hamit Altıparmak, Murat Tüzünkan   +3 more
doaj   +1 more source

Elevated fetal steroidogenic activity in autism

Molecular Psychiatry, 2014
Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor.
S. Baron-Cohen, B. Auyeung, Bent Nørgaard-Pedersen, D. Hougaard, M. Abdallah, Lars Melgaard, Arieh S Cohen, B. Chakrabarti, Liliana Ruta, M. Lombardo   +9 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression

Protein & Cell, 2015
Increasing evidence demonstrated that exogenous plant miRNAs in the diet can be absorbed and are found in mammalian tissues. These miRNAs influence the physiological and pathological progression of the recipient.
Jing Li, Yujing Zhang, Dameng Li, Yuchen Liu, Danping Chu, Xiaohong Jiang, Dongxia Hou, Ke Zen, Chen-Yu Zhang   +8 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Noninvasive prenatal testing for β-thalassemia by targeted nanopore sequencing combined with relative haplotype dosage (RHDO): a feasibility study

Scientific Reports, 2021
Noninvasive prenatal testing (NIPT) for single gene disorders remains challenging. One approach that allows for accurate detection of the slight increase of the maternally inherited allele is the relative haplotype dosage (RHDO) analysis, which requires ...
Fuman Jiang, Weiqiang Liu, Longmei Zhang, Yulai Guo, Min Chen, Xiaojing Zeng, Yang Wang, Yufan Li, JiaJia Xian, BoLe Du, Yuhuan Xie, Shuming Ouyang, Sheng Li, Yinghong Yang, Chunsheng Zhang, Fei Luo, Xiaofang Sun   +16 more
doaj   +1 more source