Results 81 to 90 of about 9,877,071 (357)

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Noninvasive prenatal testing for β-thalassemia by targeted nanopore sequencing combined with relative haplotype dosage (RHDO): a feasibility study

Scientific Reports, 2021
Noninvasive prenatal testing (NIPT) for single gene disorders remains challenging. One approach that allows for accurate detection of the slight increase of the maternally inherited allele is the relative haplotype dosage (RHDO) analysis, which requires ...
Fuman Jiang, Weiqiang Liu, Longmei Zhang, Yulai Guo, Min Chen, Xiaojing Zeng, Yang Wang, Yufan Li, JiaJia Xian, BoLe Du, Yuhuan Xie, Shuming Ouyang, Sheng Li, Yinghong Yang, Chunsheng Zhang, Fei Luo, Xiaofang Sun   +16 more
doaj   +1 more source

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia

Frontiers in Genetics, 2022
Reactivation of γ-globin expression is a promising therapeutic approach for β-hemoglobinopathies. Here, we propose a novel Cas9/AAV6-mediated genome editing strategy for the treatment of β-thalassemia: Natural HPFH mutations −113A > G, −114C > T ...
Dian Lu, Zhiliang Xu, Zhiyong Peng, Yinghong Yang, Bing Song, Zeyu Xiong, Zhirui Ma, Hongmei Guan, Bangzhu Chen, Yukio Nakamura, Juan Zeng, Nengqing Liu, Xiaofang Sun, Diyu Chen   +13 more
doaj   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression

Protein & Cell, 2015
Increasing evidence demonstrated that exogenous plant miRNAs in the diet can be absorbed and are found in mammalian tissues. These miRNAs influence the physiological and pathological progression of the recipient.
Jing Li, Yujing Zhang, Dameng Li, Yuchen Liu, Danping Chu, Xiaohong Jiang, Dongxia Hou, Ke Zen, Chen-Yu Zhang   +8 more
semanticscholar   +1 more source

Quantifying Residual Motion Artifacts in Fetal fMRI Data [PDF]

arXiv, 2020
Fetal functional Magnetic Resonance Imaging (fMRI) has emerged as a powerful tool for investigating brain development in utero, holding promise for generating developmental disease biomarkers and supporting prenatal diagnosis. However, to date its clinical applications have been limited by unpredictable fetal and maternal motion during image ...
arxiv  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Application of the amniotic fluid metabolome to the study of fetal malformations, using Down syndrome as a specific model

Molecular Medicine Reports, 2017
Although monitoring and diagnosis of fetal diseases in utero remains a challenge, metabolomics may provide an additional tool to study the etiology and pathophysiology of fetal diseases at a functional level. In order to explore specific markers of fetal
Jun Huang, Jinhua Mo, Guili Zhao, Qiyin Lin, Guanhui Wei, Weinan Deng, Dunjin Chen, Bolan Yu   +7 more
semanticscholar   +1 more source

Fetal Pose Estimation in Volumetric MRI using a 3D Convolution Neural Network [PDF]

arXiv, 2019
The performance and diagnostic utility of magnetic resonance imaging (MRI) in pregnancy is fundamentally constrained by fetal motion. Motion of the fetus, which is unpredictable and rapid on the scale of conventional imaging times, limits the set of viable acquisition techniques to single-shot imaging with severe compromises in signal-to-noise ratio ...
arxiv  

Fetal-BET: Brain Extraction Tool for Fetal MRI [PDF]

arXiv, 2023
Fetal brain extraction is a necessary first step in most computational fetal brain MRI pipelines. However, it has been a very challenging task due to non-standard fetal head pose, fetal movements during examination, and vastly heterogeneous appearance of the developing fetal brain and the neighboring fetal and maternal anatomy across various sequences ...
arxiv