Results 81 to 90 of about 24,724 (259)

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

open access: yesCell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang   +6 more
wiley   +1 more source

Artificial Intelligence in Fetal Echocardiography

open access: yesИнновационная медицина Кубани
Background: Congenital heart diseases (CHD) are one of the most common birth defects, occurring in 5-9 per 1000 newborns. CHD are the second leading cause of infant mortality and account for 47% of all causes of death from birth defects.The main method ...
E. L. Bokerija   +4 more
doaj   +1 more source

Functional Assessment of Fetal Heart by Echocardiography in Maternal Diabetes Mellitus

open access: diamond, 2022
Arwa Ashraf Mohamed   +3 more
openalex   +2 more sources

Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Systemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis of the skin and/or internal organs. Emerging evidence suggests that subcutaneous adipose tissue may contribute to systemic inflammation and fibrosis in SSc.
Marija Geroldinger‐Simić   +3 more
wiley   +1 more source

ZFP36 inhibits the pro‐apoptotic effects of transforming growth factor β1 on mitral valve interstitial cells via the GTP‐binding protein 6 pathway in mitral valve prolapse

open access: yesExperimental Physiology, EarlyView.
Abstract The objective of this work was to investigate the role of ZFP36 in mitral valve prolapse (MVP). Mitral valve and plasma were collected to assess the expression of ZFP36, transforming growth factor β (TGF‐β), collagen and elastin and apoptosis rates.
Meng Zhao   +9 more
wiley   +1 more source

Efficient in vivo targeting of the myocardial scar using Moloney murine leukaemia virus complexed with nanoparticles

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The complexation of Moloney murine leukaemia virus (MMLV) with magnetic nanoparticles (MNP) greatly enhanced the transduction of (myo)fibroblasts (FB), when applied in a magnetic field, both in vitro and in vivo in cryoinjured mice.
Timo Mohr   +11 more
wiley   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson   +1 more
wiley   +1 more source

Role of reactive oxygen species in mediating peripheral hypoxic vasodilation and sympathoexcitation at high altitude

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude acclimatisation increases muscle sympathetic nerve activity (MSNA) via activation of the arterial chemoreflex, pulmonary arterial baroreceptors and resetting of the sympathetic vascular baroreflex. However attempting to silence these mechanisms only partially normalises MSNA, implicating other contributory ...
Liam D. Corr   +15 more
wiley   +1 more source

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