Results 111 to 120 of about 1,183,127 (308)
Factors Predicting Fetal Growth Restriction and Fetal Cardiac Remodeling
International Journal of General MedicineXiaoLe Chen, Lili Xiao, Daozhu Wu, Saida Pan Department of Ultrasonic Diagnosis, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Saida Pan ...
Chen X, Xiao L, Wu D, Pan S
doaj
Predicting Fetal Growth with Curve Fitting and Machine Learning
BioengineeringMonitoring fetal growth throughout pregnancy is essential for early detection of developmental abnormalities. This study developed a Taiwan-specific fetal growth reference using a web-based data collection platform and polynomial regression modeling.
Huan Zhang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Scandinavian Journal of Work, Environment & HealthOBJECTIVE: Psychosocial work stress is a predictor of adverse pregnancy outcomes. However, there is limited comprehensive and conclusive evidence available on the associations between psychosocial work stress and adverse pregnancy outcomes.
Wubet Taklual Admas +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth
The Journal of Clinical Investigation, 2023 Alice E. Hughes +5 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Body composition in early childhood : Parental, fetal, postnata and genetic determinants of fat, lean and bone mass. The Generation R Study [PDF]
, 2011 Th e prevalence of childhood overweight and obesity has increased dramatically in developed countries over the past two decades. Childhood obesity is associated with short-term morbidity such as asthma and psychological problems and with an increased ...
Ay, L. (Lamise)
core +2 more sources