Results 141 to 150 of about 5,983,305 (250)

First-Trimester Maternal CALLY Index Is Associated With Fetal Growth Restriction. [PDF]

Am J Reprod Immunol
Karakus E, Yahsi AF, Katipoglu K.
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction. [PDF]

Nat Med
Miao R, Gong S, Sovio U, Aye ILMH, Avellino G, Guettler J, Rogers SN, Cook E, Toribio A, Bergman L, Lager S, Wikström AK, IMPACT Consortium, Kirk PDW, Charnock-Jones DS, Smith GCS.   +15 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The Effects of Maternal Prepregnancy Obesity and Excessive Gestational Weight Gain on Fetal Growth: A Longitudinal Fetal Growth Study on a Chinese Cohort. [PDF]

Matern Fetal Med
Zhai Y, Zhao Y, Li X, Gu W, Li W, Qiu Y, Li S, Sun M, Li X, Qiu W, Ma J, Feng Y, Liang Y, Gong X, Li J, Wei Y, Wu T.   +16 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

In Vivo Assessment of Placental Structure and Perfusion in Late-Gestation Pregnancies and Their Association With Fetal Growth. [PDF]

NMR Biomed
Link-Sourani D, Avisdris N, Shao X, Schonberger D, Rabinowich A, Fadida BS, Wexler Y, Joskowicz L, Sira LB, Hiersch L, Wang DJJ, Bashat DB.   +11 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Brain sparing in fetal growth restriction: The double-edged sword of fetal hypoxaemia. [PDF]

J Physiol
Allison BJ, White TA, Camm EJ, Miller SL.   +3 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source