Results 191 to 200 of about 765,322 (265)

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Decomposition of longitudinal disparities: an application to the fetal growth-singletons study. [PDF]

Biostatistics
Lee SK, Kim S, Kim MO, Grantz KL, Hong HG.   +4 more
europepmc   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Hofbauer Cells in Pregnancies Complicated by Gestational Diabetes Mellitus and Pathological Fetal Growth. [PDF]

Am J Reprod Immunol
Fakonti G, Mappa G, Orsi N, Scott EM, Holder B, Forbes K.   +5 more
europepmc   +1 more source

Fructose‐Based Single‐Chain Polymer Nanoparticles for GLUT1–Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance

Advanced Healthcare Materials, EarlyView.
Single‐chain nanoparticles have been proposed as drug delivery carriers, but adding a tail can significantly enhance their performance. This was demonstrated using a tadpole‐like structure comprising a head prepared from a UV‐crosslinked fructose‐based glycopolymer capable of targeting GLUT receptors, combined with a PEG‐based tail. Compared with other
Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y. Lai, Fariba Dehghani, Martina H. Stenzel   +6 more
wiley   +1 more source

Moderate neuroprotection of combination cell therapy in fetal growth restricted newborns at postnatal day 10. [PDF]

Stem Cells Transl Med
Chand KK, Beecher K, Nano R, Sim SL, Sun J, Stokes-Marshall P, Macfarlane L, Luff J, Musco H, Colditz PB, Khosrotehrani K, Patel J, Wixey JA.   +12 more
europepmc   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

Antenatal melatonin for cardiovascular deficits in fetal growth restriction. [PDF]

J Physiol
Rock CR, White TA, Piscopo BR, Sutherland AE, Pham Y, Karozis C, Cousins FL, Camm EJ, Miller SL, Allison BJ.   +9 more
europepmc   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Maternal Oxidative Stress Biomarkers Across Pregnancy in Relation to Fetal Growth: Evidence from the TIDES Cohort. [PDF]

Am J Epidemiol
Baghsheikhi H, Trasande L, Manuel RSJ, Shahin S, Cajachagua-Torres KN, Duh-Leong C, Kannan K, Barrett ES, Bush NR, Nguyen RH, Swan SH, Sathyanarayana S, Stevens D, Ferguson KK, Cowell W.   +14 more
europepmc   +1 more source