This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah+9 more
wiley +1 more source
Prenatal Bisphenol A Exposure Impairs Fetal Heart Development: Molecular and Structural Alterations with Sex-Specific Differences. [PDF]
Marrone A+8 more
europepmc +1 more source
Printing and Rerouting of Elastic and Protease Responsive Shape Memory Hydrogel Filaments
A biofabrication strategy, Rerouting of Free‐Floating Suspended Hydrogel Filaments (REFRESH), is developed enabling the printing of highly elastic, reconfigurable protease‐responsive hydrogel filaments with shape memory properties. The filaments can be manually braided, knotted, and rerouted to create intricate cell‐laden 3D architectures, expanding ...
Philip Lifwergren+10 more
wiley +1 more source
Computer-aided assessment for enlarged fetal heart with deep learning model. [PDF]
Nurmaini S+11 more
europepmc +1 more source
The appearance and development of fetal heart activity in the early human pregnancy
R. Schats+5 more
openalex +1 more source
Randomised controlled trial of intrapartum fetal heart rate monitoring [PDF]
Kassam Mahomed+4 more
openalex +1 more source
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng+7 more
wiley +1 more source
Proposing a machine learning-based model for predicting nonreassuring fetal heart. [PDF]
Roozbeh N+4 more
europepmc +1 more source
Changes in the fetal heart rate of thoroughbred horse through the gestation.
Kanji MATSUI+2 more
openalex +2 more sources
Effects of Electronic Fetal-Heart-Rate Monitoring, as Compared with Periodic Auscultation, on the Neurologic Development of Premature Infants [PDF]
Kirkwood K. Shy+8 more
openalex +1 more source