Results 261 to 270 of about 908,670 (370)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui   +17 more
wiley   +1 more source

UNSUPERVISED CLUSTERING AND ANALYSIS OF CONTRACTION-DEPENDENT FETAL HEART RATE SEGMENTS. [PDF]

open access: yesProc IEEE Int Conf Acoust Speech Signal Process, 2022
Yang L   +3 more
europepmc   +1 more source

Sympathetic neural activation does not mediate heart rate variability during repeated brief umbilical cord occlusions in near‐term fetal sheep

open access: yesJournal of Physiology, 2016
Christopher A. Lear   +7 more
semanticscholar   +1 more source

Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation

open access: yesAdvanced Science, EarlyView.
This study presents a novel porous drug‐loading coating for cochlear electrodes, utilizing MA‐PDMS infused with GelMA hydrogel containing dexamethasone and MXene nanoparticles. The coating enhances biocompatibility, enables sustained drug release, reduces fibrosis, and preserves residual hearing post‐CI.
Lei Ren   +15 more
wiley   +1 more source

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

open access: yesAdvanced Science, EarlyView.
This study reveals histone lactylation as a metabolic‐epigenetic regulator countering cellular senescence and skeletal muscle aging. Reduced lactylation impairs cell cycle, DNA repair and proteostasis pathways, while exercise restores glycolytic activity and lactylation levels, preserving muscle function.
Fanju Meng   +16 more
wiley   +1 more source

IMPROVING PHASE-RECTIFIED SIGNAL AVERAGING FOR FETAL HEART RATE ANALYSIS. [PDF]

open access: yesProc IEEE Int Conf Acoust Speech Signal Process, 2022
Chen T   +4 more
europepmc   +1 more source

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