Results 111 to 120 of about 115,549 (302)

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

The Ag-195 (C®G) mutation in hereditary persistence of fetal hemoglobin is not associated with activation of a reporter gene in vitro

Brazilian Journal of Medical and Biological Research, 2001
Hereditary persistence of fetal hemoglobin is an uncommon, benign disorder in which the expression of gamma-globin genes persists into adult life. Several point mutations have been associated with the increased gamma-globin gene promoter activity.
Schreiber R., Gonçalves M.S., Junqueira M.L., Saad S.T.O., Krieger J.E., Costa F.F.   +5 more
doaj  

[Fetal hemoglobin].

Postepy higieny i medycyny doswiadczalnej, 1991
The paper presents a current state of knowledge on the regulation of Hb synthesis in physiology and pathology. Possible mechanisms of HbF synthesis switching and an influence of different drugs on HbF production have been described.
openaire   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]

, 2016
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto, Azad, Priti, Bafna, Vineet, Cabrales, Pedro J, Haddad, Gabriel G, Hsiao, Yu Hsin, Poulsen, Orit, Ronen, Roy, Zhao, Huiwen W, Zhou, Dan   +9 more
core  

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Assessing maternal and perinatal complication incidence in pregnant patients with sickle cell disease: a retrospective analysis of transfusion therapy at a tertiary care hospital

Frontiers in Hematology
BackgroundPregnant individuals with sickle cell disease (SCD) face high maternal and fetal complication rates. While some studies suggest transfusions may improve outcomes, evidence is limited.
Ram Prakash Thirugnanasambandam, John Muthu   +1 more
doaj   +1 more source

Fetal Hemoglobin Levels in Various Conditions

Eurasian Journal of Medicine, 2019
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Mahmut Celal Apaydın, Salih Kocaoğlu
doaj  

Development of a new staining protocol for the Kleihauer–Betke test to facilitate the reading of difficult cases

BMC Pregnancy and Childbirth
Background The Kleihauer–Betke (KB) test allows the detection of fetal red blood cells (containing fetal hemoglobin, HbF) in the maternal blood to identify and quantify potential fetal-maternal hemorrhages.
Adrian Serban, Yannick Tholance, Carmen Aanei, Lydia Campos, Cristina Iobagiu   +4 more
doaj   +1 more source