Results 321 to 330 of about 834,624 (377)

Near‐Infrared‐Triggered Nanodroplets for Imaging‐Guided Macrophage‐Mediated Cancer Immunotherapy

Small Methods, EarlyView.
Schematic illustration of the Nanodroplets and their theranostics application–The engineered nanodroplets integrate a multifunctional design, encapsulating the immunostimulant resiquimod (R848), indocyanine green (ICG), and volatile perfluoropentane (PFP), within a biocompatible double‐emulsion structure.
Junxi Yi, Meenakshi Chauhan, Yang Zhao, Yun‐Sheng Chen   +3 more
wiley   +1 more source

Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34⁺ cell therapy to induce fetal hemoglobin for sickle cell disease. [PDF]

Mol Ther
Katta V, O'Keefe K, Li Y, Mayuranathan T, Lazzarotto CR, Wood RK, Levine RM, Powers A, Mayberry K, Manquen G, Yao Y, Zhang J, Jang Y, Nimmagadda N, Dempsey EA, Lee G, Uchida N, Cheng Y, Fazio F, Lockey T, Meagher M, Sharma A, Tisdale JF, Zhou S, Yen JS, Weiss MJ, Tsai SQ.   +26 more
europepmc   +1 more source

Sphingosine‐1‐Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety

United European Gastroenterology Journal, EarlyView.
ABSTRACT Ulcerative colitis is a chronic immune‐mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate‐to‐severe ulcerative colitis, significantly improving its management.
Massimo C. Fantini, Diego Centonze, Giovanni Giacobazzi, Silvia Benemei, Emanuele Romeo   +4 more
wiley   +1 more source

Addendum to consensus opinion from the International Deep Endometriosis Analysis (IDEA) group: sonographic evaluation of superficial endometriosis

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Traditionally, laparoscopy was considered to be the gold standard for the examination of endometriotic lesions, because it allows their direct visualization. Several international and national guidelines have now shifted their focus to non‐invasive imaging‐based diagnosis of deep endometriosis in preference to surgery, while laparoscopy is ...
S. Guerriero, G. Condous, M. Rolla, M. Pedrassani, M. Leonardi, G. Hudelist, S. Ferrero, J. L. Alcazar, S. Ajossa, C. Bafort, D. Van Schoubroeck, T. Bourne, T. Van den Bosch, S. S. Singh, M. S. Abrao, A. Di Giovanni, C. Tomassetti, D. Timmerman   +17 more
wiley   +1 more source

A Rare Case of Multiple Bone Infarctions and Abnormal Pulmonary Function Tests in a Patient With Compound Heterozygous Hemoglobin S and Type 2 Hereditary Persistence of Fetal Hemoglobin. [PDF]

Cureus
Alnaqbi KA.
europepmc   +1 more source

GENOME WIDE DNA METHYLATION PROFILING IS PREDICTIVE OF OUTCOME IN JUVENILE MYELOMONOCYTIC LEUKEMIA [PDF]

, 2017
Costello, J, Flotho, C, Geng, H, Lipka, D, Loh, M, Mazor, T, Olshen, A, Plass, C, Stieglitz, E   +8 more
core   +1 more source

Characterizing fetoplacental response to acute maternal hyperoxygenation in suspected coarctation of aorta using fetal cardiac MRI

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To characterize the fetoplacental response to acute maternal hyperoxygenation (AMH) in fetuses with suspected coarctation of the aorta (CoA) using fetal cardiac magnetic resonance imaging (MRI). Methods Pregnant women carrying a fetus with suspected CoA were recruited prospectively from a tertiary fetal cardiology center as part of ...
M. P. M. van Poppel, J. K. Steinweg, T. Woodgate, V. Zidere, T. Day, J. Hutter, R. Razavi, J. M. Simpson, T. Vigneswaran, K. Pushparajah, D. F. A. Lloyd   +10 more
wiley   +1 more source

Detection of Asymptomatic Sickle Cell Hemoglobin Carriers and Fetal Hemoglobin Regulating Genetic Variants in African Descendants from Oaxaca, Mexico. [PDF]

Anemia
Romero-Tlalolini MLÁ, Aguilar-Ruiz SR, Baltiérrez-Hoyos R, Vargas-Arzola J, Hernández-Osorio LA, Vásquez-Garzón VR, Bernardino-Hernández HU, Torres-Aguilar H.   +7 more
europepmc   +1 more source

Smart Temperature‐Sensitive Injectable Methylcellulose‐Based Hydrogels: Design and Optimization for Sustained Drug Release

VIEW, EarlyView.
MC‐based thermoreversible hydrogels were prepared and characterized. The MC/PEG hydrogel demonstrated sustained release of Dox, with rapid gelation time and the feasibility of controlling the drug release rate with temperature changes. Wide‐spectrum biocompatibility of the MC/PEG hydrogel was demonstrated, along with its ability to significantly reduce
Francesca Persano, Leonardo Lamanna, Marco Friuli, Andrea Claudio Stetco, Amilcare Barca, Tiziano Verri, Cosimino Malitesta, Christian Demitri, Elisabetta Mazzotta   +8 more
wiley   +1 more source

Simvastatin-Mediated Nrf2 Activation Induces Fetal Hemoglobin and Antioxidant Enzyme Expression to Ameliorate the Phenotype of Sickle Cell Disease. [PDF]

Antioxidants (Basel)
Xi C, Palani C, Takezaki M, Shi H, Horuzsko A, Pace BS, Zhu X.   +6 more
europepmc   +1 more source