Results 51 to 60 of about 2,098,439 (287)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Factors in Infancy That May Predict Autism Spectrum Disorder
Brain Sciences, 2023 The global increase in the prevalence of ASD (Autism Spectrum Disorder) is of great medical importance, but the reasons for this increase are still unknown.
Mina Gurevitz, Gerry Leisman
doaj +1 more source
Modeling the biomechanics of fetal movements [PDF]
Biomechanics and Modeling in Mechanobiology, 2015 Fetal movements in the uterus are a natural part of development and are known to play an important role in normal musculoskeletal development. However, very little is known about the biomechanical stimuli that arise during movements in utero, despite these stimuli being crucial to normal bone and joint formation.
Verbruggen, S.W. +6 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Automated Software Analysis of Fetal Movement Recorded during a Pregnant Woman's Sleep at Home.
PLoS ONE, 2015 Fetal movement is an important biological index of fetal well-being. Since 2008, we have been developing an original capacitive acceleration sensor and device that a pregnant woman can easily use to record fetal movement by herself at home during sleep ...
Kyoko Nishihara +4 more
doaj +1 more source
Effects of Maternal Dexamethasone Administration on Daily Foetal Movement Count and its Correlation with Doppler Studies and NonStress Test [PDF]
Al-Azhar International Medical JournalBackground: Preterm delivery causes significant infant morbidity and mortality worldwide. Fetal lung maturity is often improved with antenatal corticosteroids like dexamethasone; however, several reports have suggested a noticeable reduction in fetal ...
Maryam Elbendary +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
fetal movement acceleration data
, 2019 This dataset contains accelerometer-recorded fetal movement signals with 16 different pregnant women The dataset contains signals from one accelerometer placed on the abdominal wall of the pregnant women.
Zhao, Xin +5 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source