Results 111 to 120 of about 560,992 (241)

Monkeypox infection in pregnancy, maternal and fetal outcomes: a systematic review

Journal of Infection in Developing Countries
Introduction: Monkeypox (mpox) is an emerging infectious disease with increasing global incidence. Limited evidence exists regarding its impact on pregnancy and perinatal outcomes, especially in low-resource settings. The objective was to systematically
Jose Camones-Huerta, Alexander Cordero-Campos, Alheli Cuya-Sahua, Susana Guzmán-Carrasco, Leslie Condori-Quispe, Karina Chin-Wu, Gustavo Quispe-Villegas, Mónica Flores-Noriega   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Maternal and Fetal Implications of Gestational Diabetes Mellitus: A Retrospective, Longitudinal Study

Clinical Diabetology
OBJECTIVE: This study followed Diabetes in Pregnancy Study Group India (DIPSI) guidelines and compared the clinical profiles, and maternal and fetal outcomes of pregnant women with gestational glucose intolerance (GGI) and gestational diabetes mellitus ...
Sanjay A. Gupte, Chandrakant Rao, Gayatri Venkataraman, Aarti S. Shah, Shweta M. Jangam, Manasi Kunte, Deepti Salunkhe, Shridevi Gundu   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Effectiveness of antihypertensive therapies and maternal-neonatal outcomes in preeclampsia and eclampsia women: an analytical retrospective study from sudan

Journal of Family Medicine and Primary Care
Background: Preeclampsia and eclampsia (PE/E) are significant contributors to maternal and perinatal morbidity and mortality globally. While international guidelines suggest various drugs for managing these conditions, their efficacy in the Sudanese ...
Esraa O. Mohammed, Qusay O. Abdalla, Kannan O. Ahmed, Elmoiz Babekir, Khalid A. Ateyyah, Hamza A. Awad, Osama K. Khattab, Bashir A. Yousef   +7 more
doaj   +1 more source

Intrafamily Resource Allocations: A Dynamic Model of Birth Weight [PDF]

This paper estimates a model of dynamic intrahousehold investment behavior which incorporates family fixed effects and child endowment heterogeneity. This framework is applied to large American and British survey data on birth outcomes, with focus on the
Del Bono, Emilia, Ermisch, John, Francesconi, Marco   +2 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source