Results 121 to 130 of about 560,992 (241)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Association between serum albumin and 42-day postpartum mortality in women with acute fatty liver of pregnancy: a retrospective study

Frontiers in Medicine
IntroductionAcute Fatty Liver of Pregnancy (AFLP) is a rare, life-threatening complication during pregnancy, characterized by acute liver failure, endangering both mother and fetus. Albumin (ALB), synthesized by the liver, is vital for maintaining plasma
Yuxin Fang, Yuxin Fang, Guangyuan Liao, Guangyuan Liao, Xiangbin Li, Xiangbin Li, Yi Fang, Yi Fang, Yuanmei Gao   +8 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Association of placental location during the second and third trimesters with feto-maternal complications and delivery methods

MGM Journal of Medical Sciences
Background: Placental location plays a crucial role in pregnancy outcomes by influencing uteroplacental blood flow, which affects both maternal and fetal health.
Anam Wasil, Rupali Gupta, Abhilasha Parihar, Shambhavi Tripathi   +3 more
doaj   +1 more source

Effects of Hydroxychloroquine on Maternal and Fetal Outcomes in Pregnant Patients with Lupus: A Systematic Review and Meta-Analysis

Clinical and Experimental Obstetrics & Gynecology
Background: The effects of hydroxychloroquine (HCQ) on maternal and fetal outcomes in pregnant patients with systemic lupus erythematosus (SLE) have not been fully elucidated in recent research.
An-Hao Liu, Xiu-Wen Li, Yue-Wen Yu, Bin Xu, Rui Lei, Chong Ren, Xue-Ru Ruan, Li-Li Tian, Yu-Ping Ma, Ming-Zhu Ye, Xiu-Min Huang, Xun Chen   +11 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Comparison of Modified Labor Induction Strategies for Pregnant Women at a Single Tertiary Center Before and During the COVID-19 Pandemic

Diagnostics
Background: The COVID-19 pandemic has substantially impacted healthcare systems and obstetric practices worldwide. Labor induction is a common procedure for preventing obstetric complications in high-risk populations.
Yi-Sin Tan, Ching-Chang Tsai, Hsin-Hsin Cheng, Yun-Ju Lai, Pei-Fang Lee, Te-Yao Hsu, Kun-Long Huang   +6 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Tryptophan as a biomarker of pregnancy-related immune expression and modulation: an integrative review

Frontiers in Reproductive Health
BackgroundDegradation pathways of Tryptophan (TRP) are implicated in a spectrum of physiological adaptations and outcomes associated with pregnancy.
Stephanie Prescott, Stephanie Prescott, Natasa Billeci, Melissa Gotcher, Sapna Patel, Addison Almon, Hailey Morgan, Danielle Abukhalaf, Maureen Groer   +8 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source