Results 111 to 120 of about 2,560,680 (304)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus

Biological Research
Background Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenatal stress induces functional and/or
Mario Sánchez-Rubio, Lorena Abarzúa-Catalán, Ana del Valle, Maxs Méndez-Ruette, Natalia Salazar, Jacinta Sigala, Soledad Sandoval, María Inés Godoy, Alejandro Luarte, Lara J. Monteiro, Roberto Romero, Mahesh A. Choolani, Úrsula Wyneken, Sebastián E. Illanes, Luis Federico Bátiz   +14 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Effects of maternal jujube fruit powder supplementation on cholinergic and synaptic protein expression in the fetal brain of rats

Journal of Functional Foods
Maternal nutrition and dietary bioactive compounds may influence fetal development during gestation. The present study investigated the effects of maternal supplementation with the jujube fruit powder (JFP) on on antioxidant responses and ...
Jiwon Jeong, Ja Young Jang, Yunseo Choi, Seung Hyeon Lee, Heon-Sang Jeong, Yun-Bae Kim, Dongsun Park   +6 more
doaj   +1 more source

Fetal growth retardation and lack of hypotaurine in ezrin knockout mice.

PLoS ONE, 2014
Ezrin is a membrane-associated cytoplasmic protein that serves to link cell-membrane proteins with the actin-based cytoskeleton, and also plays a role in regulation of the functional activities of some transmembrane proteins. It is expressed in placental
Tomohiro Nishimura, Kei Higuchi, Yoshimichi Sai, Yuki Sugita, Yuko Yoshida, Masatoshi Tomi, Masami Wada, Tomohiko Wakayama, Atsushi Tamura, Sachiko Tsukita, Tomoyoshi Soga, Emi Nakashima   +11 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Abruptio placentae during fetal myelomeningocele repair

, 2015
Myelomeningocele (MM) is a congenital neural tube defect with serious consequences, including hydrocephaly. An important hope for intrauterine repair is that hydrocephaly may be prevented by reversing the Arnold-Chiari malformation. Three medical centers
Cursino, K, Zambelli, H, Prando, Adilson, Barini, R, Cursino, Kleber, Barreto, MWG, Barini, Ricardo, Sbragia, Lourenço, Sbragia, L, Barreto, Maria Weber G, Prando, A, Zambelli, Herder   +11 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reducing alcohol-exposed pregnancies; a report of the National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect [PDF]

"This report is a collaborative effort of the National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect (NTFFASFAE), the Centers for Disease Control and Prevention's (CDC) National Center on Birth Defects and Developmental Disabilities ...

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Fetal alcohol spectrum disorders: a review of interventions for prevention and management in Indigenous communities [PDF]

, 2015
This resource sheet provides estimates on the prevalence of fetal alcohol spectrum disorders in the general and Indigenous populations of Australia, and reviews the local and international evidence on the effectiveness of programs that aim to prevent or ...
Closing the Gap Clearinghouse
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