Results 21 to 30 of about 3,339 (218)

Suggested Mechanisms of Tracheal Occlusion Mediated Accelerated Fetal Lung Growth: A Case for Heterogeneous Topological Zones

Frontiers in Pediatrics, 2018
In this article, we report an up-to-date summary on tracheal occlusion (TO) as an approach to drive accelerated lung growth and strive to review the different maternal- and fetal-derived local and systemic signals and mechanisms that may play a ...
Ahmed I. Marwan, Uladzimir Shabeka, Evgenia Dobrinskikh   +2 more
doaj   +1 more source

Spina Bifida: A Review of the Genetics, Pathophysiology and Emerging Cellular Therapies

Journal of Developmental Biology, 2022
Spina bifida is the most common congenital defect of the central nervous system which can portend lifelong disability to those afflicted. While the complete underpinnings of this disease are yet to be fully understood, there have been great advances in ...
Abd-Elrahman Said Hassan, Yimeng Lina Du, Su Yeon Lee, Aijun Wang, Diana Lee Farmer   +4 more
doaj   +1 more source

Role of fetal surgery in spinal dysraphism

Indian Journal of Neurosurgery, 2013
Open spinal dysraphism is a common and clinically challenging organo-genetic malformation. Due to the well-known multi-organ affection with significant implication on the lives of patients and their families, abortion after prenatal diagnosis became ...
A. Martina Messing-Jünger
doaj   +1 more source

Spinal cord untethering after fetal myelomeningocele repair

Archives of Pediatric Neurosurgery, 2021
The incidence of tethered cord syndrome after myelomenigocele (MMC) repair is higher in patients undergoing in utero than postnatally. However, a paucity of studies have described the details of untethering in children which MMC was corrected during ...
Leopoldo Mandic Furtado, José Aloysio da Costa Val Vilho, José Antônio Lima Vieira, Aieska Kellen Dantas dos Santos   +3 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Quantifying prenatal and postnatal mortality in extreme early onset fetal growth restriction: A systematic review and incidence analysis

Pregnancy
Background and Objective Extreme early‐onset fetal growth restriction (EE‐FGR) is associated with significant perinatal morbidity and mortality. As short‐ and long‐term prognoses are influenced by both gestational age and severity of FGR, quantifying ...
Shohra Qaderi, Giulia Bonanni, Mohammadamin Parsaei, Ehsan Rojhani, Satjeet Deol Chauhan, Eyal Krispin, Dario O. Fauza, Anna L. David, Kjersti Aagaard, Alireza A. Shamshirsaz   +9 more
doaj   +1 more source

Evolução de 58 fetos com meningomielocele e o potencial de reparo intra-útero Fetal myelomeningocele and the potential in-utero repair: follow-up of 58 fetuses

Arquivos de Neuro-Psiquiatria, 2004
INTRODUÇÃO: O diagnóstico pré natal da meningomielocele (MM) permite melhor planejamento de sua abordagem e, mais recentemente , um possível reparo intra-útero.
Lourenço Sbragia, Isabela Nelly Machado, Carlos Eduardo Braidos Rojas, Helder Zambelli, Márcio Lopes Miranda, Maria Otília Bianchi, Ricardo Barini   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Decreasing trend of gastroschisis prevalence in the United States from 2014 through 2022: Is attributed to declining birth rates in young, high-risk gravidae

European Journal of Obstetrics & Gynecology and Reproductive Biology: X
Objectives: To investigate the prevalence trend of gastroschisis in the United States between 2014 and 2022. Methods: A cross-sectional retrospective analysis of the Centers for the United States live births between 2014 and 2022.
Hiba J. Mustafa, Nikan Zargarzadeh, Kevin L. Moss, May Abiad, Brian Gray, Kjersti M. Aagaard, Terry L. Buchmiller, Erin E. Perrone, Alireza A. Shamshirsaz   +8 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source