Results 121 to 130 of about 5,593,834 (345)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Gestational Diabetes Mellitus and Antenatal Corticosteroid Therapy—A Narrative Review of Fetal and Neonatal Outcomes [PDF]

, 2022
Ivana Babović, Jelena Dotlić, Radmila Sparić, Miljana Z. Jovandarić, Mladen Andjić, Mirjana Marjanović Cvjetićanin, Slavica Akšam, Jovan Bila, Lidija Tulić, Dusica Kocijancic, Vera Plešinac, Jovana Plešinac   +11 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early‐onset fetal growth restriction

BJOG: an International Journal of Obstetrics and Gynaecology, 2019
To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early‐onset fetal growth restriction.
K. Groom, K. Groom, L. Mccowan, L. Mccowan, L. Mackay, Arier C. Lee, G. Gardener, J. Unterscheider, J. Unterscheider, R. Sekar, J. Dickinson, J. Dickinson, Peter Muller, R. Reid, D. Watson, A. Welsh, A. Welsh, Jay Marlow, S. Walker, S. Walker, J. Hyett, J. Hyett, J. Morris, P. Stone, P. Baker, P. Baker   +25 more
semanticscholar   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy [PDF]

, 2017
Jeremie H. Estepp, Matthew P. Smeltzer, Guolian Kang, Chen Li, Winfred C. Wang, Christina M. Abrams, Banu Aygün, Russell E. Ware, Kerri Nottage, Jane S. Hankins   +9 more
openalex   +1 more source

Fetal gene therapy for neurodegenerative disease of infants

Nature Network Boston, 2018
For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. To explore this, we studied neuronopathic Gaucher disease (nGD), caused by mutations in GBA.
G. Massaro, C. Mattar, A. Wong, E. Sirka, S. Buckley, B. Herbert, S. Karlsson, D. Perocheau, D. Burke, S. Heales, A. Richard-Londt, S. Brandner, Mylene Huebecker, D. Priestman, F. Platt, K. Mills, A. Biswas, J. Cooper, J. Chan, Seng H. Cheng, S. Waddington, A. Rahim   +21 more
semanticscholar   +1 more source

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]

, 2020
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source