Results 91 to 100 of about 4,656,954 (331)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ultrasonography-based Fetal Weight Estimation: Finding an Appropriate Model for an Indian Population

Journal of Medical Ultrasound, 2017
Background: Very limited information is available regarding the accuracy and applicability of various ultrasonography parameters [abdominal circumference (AC), biparietal diameter (BPD), femur length (FL), and head circumference (HC)]-based fetal weight ...
Sujitkumar S. Hiwale, Hemant Misra, Shrutin Ulman   +2 more
doaj   +1 more source

Birth weight prediction by Lee formula based on fractional thigh volume in term pregnancies – is it helpful?

Archives of Medical Science, 2020
Introduction Ultrasonographic estimation of fetal weight (EFW) is a standard obstetrical procedure in daily clinical practice. Formulas for calculating EFW most commonly are a combination of two-dimensional measurements.
Jakub Mlodawski, Daniel Wolder, Piotr Niziurski, Olga Adamczyk-Gruszka, Stanisław Głuszek, Wojciech Rokita   +5 more
doaj   +1 more source

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Human Molecular Genetics, 2018
Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation.
R. Beaumont, N. Warrington, A. Cavadino, J. Tyrrell, J. Tyrrell, M. Nodzenski, M. Horikoshi, M. Horikoshi, F. Geller, Ronny Myhre, R. Richmond, R. Richmond, R. Richmond, L. Paternoster, J. Bradfield, E. Kreiner-Møller, E. Kreiner-Møller, V. Huikari, S. Metrustry, K. Lunetta, J. Painter, J. Hottenga, J. Hottenga, Catherine Allard, S. Barton, Ana Espinosa, J. Marsh, C. Potter, Ge Zhang, Ge Zhang, W. Ang, D. Berry, L. Bouchard, L. Bouchard, Shikta Das, H. Hakonarson, H. Hakonarson, Jani Heikkinen, Ø. Helgeland, B. Hocher, B. Hocher, A. Hofman, H. Inskip, H. Inskip, Samuel E. Jones, M. Kogevinas, P. Lind, L. Marullo, S. Medland, A. Murray, J. Murray, P. Njølstad, P. Njølstad, E. Nøhr, C. Reichetzeder, C. Reichetzeder, S. Ring, S. Ring, K. Ruth, L. Santa-Marina, D. Scholtens, S. Sebert, S. Sebert, V. Sengpiel, M. Tuke, M. Vaudel, M. Weedon, G. Willemsen, G. Willemsen, A. Wood, H. Yaghootkar, L. Muglia, L. Muglia, M. Bartels, M. Bartels, C. Relton, C. Relton, C. Relton, C. Pennell, L. Chatzi, X. Estivill, J. Holloway, D. Boomsma, D. Boomsma, G. Montgomery, J. Murabito, T. Spector, C. Power, M. Jarvelin, H. Bisgaard, H. Bisgaard, S. Grant, S. Grant, T. Sørensen, T. I. Sørensen, V. Jaddoe, B. Jacobsson, M. Melbye, M. Melbye, M. McCarthy, M. McCarthy, M. McCarthy, A. Hattersley, M. Hayes, T. Frayling, M. Hivert, M. Hivert, J. Felix, E. Hyppönen, E. Hyppönen, W. Lowe, David M. Evans, David M. Evans, D. Evans, D. Lawlor, D. Lawlor, B. Feenstra, R. Freathy, R. Freathy   +118 more
semanticscholar   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Fetal ultrasound estimated weight and correlation to Brazilian newborn weight

Journal of Ultrasonography, 2020
Background: To compare the best fetal weight formula with different biometric tables on the weight of Brazilian newborns. Methods: This observational study has tested the performance of different common fetal weight formulas and biometric tables.
Galluzzo Roberto Noya, Trapani Alberto, Werner Heron, de Sá Renato Augusto Moreira, Xikota João Carlos, Araujo Edward, de Souza Pires Maria Marlene   +6 more
doaj   +1 more source

Undernutrition and stage of gestation influence fetal adipose tissue gene expression [PDF]

, 2015
Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784).
Adam, Clare L, Aitken, Raymond P, Horgan, Graham W, Luther, Justin S, Milne, John S, Redmer, Dale A, Reynolds, Lawrence P., Wallace, Jacqueline M   +7 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Role of Ultrasonography Placental Thickness in Third Trimester in the Prediction of Fetal Outcome

National Journal of Medical Research
Introduction: The Placenta is a functional unit between the mother and foetus. Placental thick play’s important role in foetal outcome. This study conducted to assess Placental Thickness ultra-sonographically at 32nd and 36th weeks of gestation and to ...
Yamini Patil, Olivia B. Skariah, Rajkumar P Patange   +2 more
doaj   +1 more source

Effects of marginal umbilical cord insertion on the prognosis of fetus

Clinical and Experimental Obstetrics & Gynecology, 2020
Objective: To investigate the effect of marginal placental insertion of the umbilical cord on the prognosis of a fetus. Material and Methods: Retrospective analysis was performed to compare the differences in fetal weight (FW), placental weight (PW ...
Y. Tian, H. Luo, M. He
doaj   +1 more source