Results 131 to 140 of about 625,486 (408)

Abortion and Moral Repugnancy [PDF]

open access: yes, 2006
Most arguments concerning abortion center around the issue of rights. This short essay argues that there can be important considerations regarding the matter that have nothing whatsoever to do with rights.
Thomas, Professor Laurence
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Fetal ultrasound: Early diagnosis and natural evolution of proximal femoral focal deficiency

open access: yesJournal of Ultrasonography, 2017
Proximal femoral focal deficiency is an extremely rare congenital anomaly with only a few case reports in the literature. This case illustrates one diagnosed by prenatal ultrasound.
Eugenio O. Gerscovich   +3 more
doaj   +1 more source

RETRACTED: Fetus-in-fetu in Botswana

open access: yesJournal of Pediatric Surgery Case Reports, 2017
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted at the request of
Chowdhury Goutam, Francis Msume Banda
openaire   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Anti-Implantation Activity of Kepel (Stelechocarpus burahol) Pulp Ethanol Extract in Female Mice [PDF]

open access: yesJournal of Pure and Applied Chemistry Research, 2015
Kepel (Stelechocarpus burahol) has been used as a contraceptive remedy in Indonesia traditional Javanese royal family. It fruit contains a toxic substances to fetus. However, few studies have been conducted on the toxic effect of kepel fruit.
Suparmi Suparmi   +7 more
doaj  

Automatic segmentation of the intracranialvolume in fetal MR images [PDF]

open access: yesarXiv, 2017
MR images of the fetus allow non-invasive analysis of the fetal brain. Quantitative analysis of fetal brain development requires automatic brain tissue segmentation that is typically preceded by segmentation of the intracranial volume (ICV). This is challenging because fetal MR images visualize the whole moving fetus and in addition partially visualize
arxiv  

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