3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram +5 more
wiley +1 more source
Successful Management of Two Consecutive Pregnancies With Maternal-Fetal Phenylketonuria: Lessons From Clinical Practice. [PDF]
Lundkvist P +3 more
europepmc +1 more source
Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt +2 more
wiley +1 more source
Prenatal diagnosis of a <i>de novo</i> pathogenic <i>HNRNPK</i> variant in a Chinese fetus with abnormal ultrasound soft markers: a case report. [PDF]
Zhu Y +5 more
europepmc +1 more source
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Discussion of the Fetus in Fetal Cardiology Consultations: A Qualitative Study. [PDF]
Syme S +8 more
europepmc +1 more source
Enzyme‐Regulated Extended Swelling of Hydrogels for Dehiscence‐Less Tissue Expansions
An interpenetrating hydrogel network with swelling under regulation by enzymatic degradation (INSURED) is fabricated to avoid dehiscence. INSURED remains structurally intact post‐implantation, while HYAL injection enables control over the onset and rate of swelling.
Byung Ik Park +10 more
wiley +1 more source
Prenatal Isolated Congenital Diaphragmatic Hernia: A Rare Clinical Presentation of a <i>GATA4</i> Pathogenic Variant. [PDF]
Tulonen N +6 more
europepmc +1 more source

