Results 171 to 180 of about 949,474 (217)

Integrated biorefinery for cellulosic ethanol and spherical nanolignin production from coconut waste

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Green coconut waste was subjected to different fractionation methods to obtain integrated lignin nanoparticles and cellulosic ethanol. Pretreatment with gradual addition of dilute sulfuric acid provided a higher structural hemicellulose precursor yield (68.2%).
Ricardo Marchezan Farias de Mesquita, Júlia Caroline Dal Prá, Roselei Claudete Fontana, Sheila Montipó, Henrique Macedo Baudel, Eduardo Dieldold, Willian Daniel Hahn Schneider, Marli Camassola   +7 more
wiley   +1 more source

Retrospective Analysis of Chronic Q Fever Cases at a Tertiary Care Center From 2007 to 2023. [PDF]

Open Forum Infect Dis
Dumais MG, Howick V JF, Garcia SM, El Zein S, Abu Saleh O.   +4 more
europepmc   +1 more source

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Adverse Events Following Yellow Fever Vaccination in Older Adults in Colombia, 2024-2025: A National Pharmacovigilance Analysis. [PDF]

Vaccines (Basel)
Vásquez-Serna H, Jiménez-Canizales CE, Huertas-Caro CA, Urrego-Ricaurte D, Vargas-Vargas JE, Forero Gutiérrez LG, Rodríguez L, Corredor O, Hurtado G, Zambrano LI, Rodríguez-Morales AJ.   +10 more
europepmc   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Genetically Distinct African Swine Fever Virus Genotype II Variant in Wild Boar, Spain, 2025-2026. [PDF]

Emerg Infect Dis
Gallardo C, Marcet-Houben M, Agüero M, Nieto R, Casado N, Soler A, Ruano MJ, Villalba R, Fernández-Pinero J, Simón A, Pérez C, Gómez C, García C, Labrador M, Argilaguet J, Coronado L, Majó N, Aguilera-Sepulveda P, Aldea I, Gabaldón T, Gómez MB, Arias M.   +21 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Projecting the future spread of yellow fever vectors and implications for epidemic risk: a scoping review of climate change and human behaviour. [PDF]

BMJ Open
Parreiras-Gonçalves A, Failloux AB, Jelinek T, LaBeaud AD, Langevin E, Ooi EE, Thollot Y, Tomori O, Vasilakis N, Lowe R, Colón-González FJ.   +10 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source