Results 211 to 220 of about 2,246,656 (386)

World Cup Watching

open access: yes, 2013
This essay describes Jack\u27s experience dealing with World Cup fever in Bath, England, during the 2010 World Cup. It\u27s Jack\u27s outsider\u27s perspective on the impact of world cup competition while he taught in the Advanced Studies in England ...
Ryan, Jack
core  

External Validation of a Multivariable Diagnostic Prediction Model for Acute Invasive Fungal Rhinosinusitis in Tertiary Care Settings

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Prompt detection and intervention are crucial for improving outcomes in acute invasive fungal rhinosinusitis (AIFS). Diagnostic prediction models assist in risk‐stratification, but their accuracy requires testing through external validation.
Aviv Spillinger   +7 more
wiley   +1 more source

De Novo Design of High‐Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

open access: yesAngewandte Chemie, EarlyView.
Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic   +18 more
wiley   +2 more sources

The Risk of Rheumatic Disorders Among Patients With Rhinosinusitis: A Systematic Review and Meta‐Analysis

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Emerging evidence suggests a possible link between rhinosinusitis and systemic rheumatic diseases; however, no meta‐analysis has comprehensively examined this association to date. We aimed to investigate if patients with rhinosinusitis have a predisposition to unmasking rheumatic diseases compared to individuals without ...
Arshbir Aulakh   +5 more
wiley   +1 more source

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft   +18 more
wiley   +1 more source

Buried Treasure? Overlooked and Newly Discovered Evolutionary Contributions to Human Brain Diseases

open access: yesAnnals of Neurology, EarlyView.
Recapitulative schema of different exploratory levels of the evolutionary impact on human neurological diseases. Clinical neuroscience focuses on the mechanisms of brain function, but this approach falls short of insights into how the central nervous system (CNS) evolved, both in health and disease.
Nico J. Diederich   +20 more
wiley   +1 more source

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