Results 41 to 50 of about 15,899 (233)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Baseline characteristics of FGA and risperidone users.

, 2013
Baseline characteristics of FGA and risperidone users.
Irina Vasilyeva (413094), Robert G. Biscontri (413095), Murray W. Enns (413096), Colleen J. Metge (413097), Silvia Alessi-Severini (413098)   +4 more
core   +1 more source

Comparison of Patellar Position After Mobile-Bearing and Fixed-Bearing TKA: A Prospective Randomized Study

Orthopaedic Journal of Sports Medicine
Objectives: Total knee arthroplasty (TKA) is the treatment of choice for severe knee osteoarthritis. While many studies compare mobile- and fixed-bearing designs, data on patellar position between these systems remains insufficient.
Abreu FGA
doaj   +1 more source

Dysfibrinogenemia and hypofibrinogenemia - Spectrum of pathogenic variants in Slovak patients

Biomedical Papers
Introduction. Congenital hypofibrinogenemia (CH) and congenital dysfibrinogenemia (CD) are rare coagulation disorders caused by quantitative or qualitative defects in the fibrinogen gene.
Dominika Jaraskova, Jan Chandoga, Angelika Batorova, Tatiana Prigancova, Miriama Juhosova, Pavol Durina, Alzbeta Vavrova, Silvia Dallemule, Robert Petrovic, Anna Kyselova, Denisa Jankovicova, Daniel Bohmer   +11 more
doaj   +1 more source

Melhoramento genético das propriedades do carvão vegetal de Eucalyptus Genetic improvement of Eucalyptus charcoal properties

Revista Árvore, 2007
Os objetivos deste trabalho foram estimar os parâmetros fenotípicos, e genotípicos, e ganhos genéticos para as propriedades do carvão vegetal e selecionar clones de Eucalyptus, por meio de características do carvão vegetal, visando à otimização da sua ...
Maria Carolina Gaspar Botrel, Paulo Fernando Trugilho, Sebastião Carlos da Silva Rosado, José Reinaldo Moreira da Silva   +3 more
doaj   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Incidence of Meniscal Ramp Lesions in Anterior Cruciate Ligament Reconstructions players

Orthopaedic Journal of Sports Medicine
Objectives To evaluate the incidence and epidemiological aspects of meniscal ramp injuries in patients undergoing anterior cruciate ligament (ACL) reconstruction, and determine the related risk factors.
FGA Abreu
doaj   +1 more source

Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review

Journal of Diabetes Research, 2019
Wound healing is a perfectly coordinated cascade of cellular, molecular, and biochemical events which interact in tissue reconstitution. Chronic diseases such as pressure ulcers (PU) and diabetes mellitus (DM) are considered risk factors for wound ...
Suélia de Siqueira Rodrigues Fleury Rosa, Mário Fabrício Fleury Rosa, Marcos Augusto Moutinho Fonseca, Glécia Virgolino da Silva Luz, Carlos Federico Domínguez Avila, Aldira Guimarães Duarte Domínguez, Aldene Guimarães Duarte Dantas, Von Braun Richter   +7 more
doaj   +1 more source

Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma

Frontiers in Oncology, 2021
Gallbladder carcinoma (GBC), which has high invasion and metastasis risks, remains the most common biliary tract malignancy. Surgical resection for GBC is the only effective treatment, but most patients miss the opportunity for curative surgery because ...
Changhong Yang, Jialei Chen, Zhe Yu, Jing Luo, Xuemei Li, Baoyong Zhou, Ning Jiang   +6 more
doaj   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source