Results 71 to 80 of about 1,412,123 (303)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Multi-wavelength fiber laser with erbium doped zirconia fiber and semiconductor optical amplifier

, 2010
Multi-wavelength hybrid fiber lasers are demonstrated in both ring and linear cavities using a fabricated Erbium-doped Zirconia fiber (EDZF) and semiconductor optical amplifier (SOA) as gain media.
Hamzah, Amirah, Ahmad, Harith, Boyland, A.J., Hamzah, A., Arof, H., Harun, S.W., Yoo, S., Paul, M.C., Pal, M., Bhadra, S.K., Huri, N.A.D., Kalita, M.P., Harun, Sulaiman Wadi, Das, S., Lokman, A., Lokman, Asiah, Pal, Manimala, Arof, Hamzah, Sahu, Jayanta Kumar, Sahu, J.K., Ahmad, H.   +20 more
core   +1 more source

Improving saccharification of ramie stalks by synergistic effect of in-house cellulolytic enzymes consortium

AMB Express, 2022
The high cost of cellulase is one of the main obstacles hindering the large-scale biorefining of lignocellulosic biomass. Therefore, developing efficient method for preparation of cellulase is promising.
Cha Cao, Zuohua Zhu, Chao Xu, Wenbing Gong, Yingjun Zhou, Li Yan, Zhenxiu Hu, Chunliang Xie, Yuande Peng   +8 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Optical fiber fabrication using novel gas-phase deposition technique [PDF]

, 2011
We report a highly versatile chemical-in-crucible preform fabrication technique suitable for gas-phase deposition of doped optical fibers. Aluminosilicate and ytterbium-doped phosphosilicate fibers are presented demonstrating the technique and its ...
David J. Richardson, Mountfort, F.H., Jayanta K. Sahu, Richardson, D.J., Mridu P. Kalita, Boyland, A.J., Webb, A.S., David N. Payne, Yoo, S., Payne, D.N., Kalita, M.P., Alexander J. Boyland, Francesca H. Mountfort, Robert J. Standish, Standish, R.J., Andrew S. Webb, Sahu, J.K., Seongwoo Yoo   +17 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Fiber and Dietary Fiber

Nippon Shokuhin Kagaku Kogaku Kaishi, 2011
繊維質とは，自然に放置しても分解されにくく，動物によっても消化されにくい成分のことを指す．本来，ヒトの消化酵素で消化されない繊維質は，生理的意義が低い非栄養素とされてきたが，難消化性の繊維質はヒトの健康維持に重要な役割を果たすことが次第に知られるようになった．食物繊維とは多糖類のひとつであるが，日本食品標準成分表2010では「ヒトの消化酵素で消化されない食品中の難消化性成分の総体」と定義されている．ヒトの炭水化物消化酵素であるアミラーゼは，デンプンを構成している糖分子のα結合を分解できるが，食物繊維を形成しているβ結合を分解する能力がない．従来，食物繊維はエネルギー源にならないと考えられていたが，実際は，消化されない食物繊維の一部が腸内細菌により発酵分解されて短鎖脂肪酸とガスになるため ...
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source