Results 61 to 70 of about 2,124,946 (303)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Influence Of Varying Mix Design And Fiber Length On The Properties Of Water Hyacinth Particle Board

open access: yesPUP Journal of Science and Technology, 2015
This study is focused on the investigation of the influence of varying mix design and fiber length on the properties of water hyacinth particleboard.
Melito Baccay
doaj   +1 more source

Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse   +13 more
wiley   +1 more source

Health Research Board Annual Report Part 2: Corporate Governance 2022 and Financial Statements [PDF]

open access: yes
Te Board of the Health Research Board (HRB) was established under Te Health Research Board (Establishment) Order 1986 (S.I. NO.279 of 1986) as amended. Te functions of the HRB are set out in Article 4 of this statutory instrument.
Health Research Board
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Minutes of the meeting of the Western Health Board 7th May 1984

open access: yes, 1984
Minutes of the regular Western Health Board meetings, held in ...
Western Health Board (WHB)
core   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram   +3 more
wiley   +1 more source

Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis

open access: yesArthritis Care &Research, EarlyView.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang   +21 more
wiley   +1 more source

Columbia Accident Investigation Board Report: Volume 6.Transcripts of Board Public Hearings

open access: yes, 2003
Sixth volume of the final report produced by the Columbia Accident Investigation Board including transcripts of board public hearings held in Houston, Texas; Cape Canaveral, Florida; and Washington ...
Columbia Accident Investigation Board
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Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

open access: yesArthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli   +13 more
wiley   +1 more source

Kansas Parole Board Annual Report, Fiscal Year 2004

open access: yes, 2004
The Kansas Prisoner Review Board was created by Executive Reorganization Order (ERO) No.34 in 2011 and succeeded to the powers, duties, and functions of the KANSAS PAROLE BOARD, which was abolished by the same ERO.
Kansas Parole Board
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