Results 31 to 40 of about 38,964 (309)
Cailiao gongchengThe damage evolution behavior of center-notched C/SiC composite components is investigated under uniaxial tensile loading by conducting in situ mechanical experiments based on synchrotron radiation X-ray CT observations with deep learning algorithms，3D ...
LIU Qiaoyu +4 more
doaj +1 more source
Clinical application of multicolor imaging in Leber hereditary optic neuropathy
Frontiers in Neurology, 2022 PurposeTo characterize features of retinal never fiber in Leber Hereditary Optic Neuropathy (LHON) using multicolor (MC) imaging and color fundus photography (CFP).MethodsNinety-two eyes of patients with LHON underwent MC imaging, optic disc spectral ...
Yufang Cheng +5 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Theoretical analysis and application of fiber bundle model based on thermodynamic energy method
AIP AdvancesIn this paper, a fiber bundle model based on the thermodynamic energy method is established. The failure analysis of the fiber bundle is incorporated into the energy system.
Yanru Wu +3 more
doaj +1 more source
Development of Optical Fiber-Based Daylighting System and Its Comparison
Energies, 2015 Fiber-optic daylighting systems have been shown to be a promising and effective way to transmit sunlight in the interior space whilst reducing electric lighting energy consumption.
Irfan Ullah, Allen Jong-Woei Whang
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
About the torsion tensor of an affine connection on two-dimensional and three-dimensional manifolds
Дифференциальная геометрия многообразий фигур, 2021 The basis for this study of affine connections in linear frame bundle over a smooth manifold is the structure equations of the bundle. An affine connection is given in this bundle by the Laptev — Lumiste method. The differential equations are written for
K.V. Polyakova
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source