Results 31 to 40 of about 55,828 (309)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Superior ablation resistance of plasma sprayed SiC based coating by structural optimized powders

Journal of Materials Research and Technology
Pristine SiC coating prepared by plasma spraying is difficult to achieve good ablation resistance at high temperature due to its weak SiO2 scale. Besides incorporation by ultra-high temperature ceramics, the modification of the SiC coating from its ...
Ting Xu, Jinhong Liu, Lingxiang Guo, Zhixiang Zhang, Jia Sun   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Superior synergistic oxidation resistance of medium-entropy carbide ceramic powders rather than multi-phase carbide ceramic powders

Journal of Advanced Ceramics
To date, some questions about medium-entropy carbide ceramics and the corresponding multi-phase carbide ceramics with the same cations and proportions remain unclear.
Jiachen Li, Fanyu Lu, Tao Li, Yanqin Fu, Junhao Zhao, Junshuai Lv, Yulei Zhang   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Fully reversible reinforcement of softwood beams with unbonded composite plates

, 2016
In this paper, results of flexure tests aimed at improving the structural behaviour of softwood beams reinforced with unglued composite plates and at developing an effective alternative to the use of organic resins are presented.
Borri, Antonio, Castori, Giulio, Speranzini, Emanuela, Corradi, Marco   +3 more
core   +1 more source

Increased electromagnetic interference shielding and load bearing with a three-dimensional pristine graphene@pyrocarbon skeleton in AZ91D

Nature Communications
The development of electronic devices for communication systems, radar warning, and satellite detection requires lightweight materials that exhibit exceptional electromagnetic interference (EMI) shielding while maintaining mechanical robustness. However,
Yuan Ma, Lingjun Guo, Yuchen Cao, Lehua Qi   +3 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Analysis of glass fiber reinforced cement (GRC) fracture surfaces

, 2010
Glass fiber reinforced cement (GRC) is a composite material produced by the union of a cement mortar matrix and chopped glass fibers. Its good mechanical properties deteriorate with time. This phenomenon has been studied performing a tensile test program
Cendón Franco, David Ángel, Enfedaque Díaz, Alejandro, Sanchez Galvez, Vicente, Gálvez Díaz-Rubio, Francisco   +3 more
core   +1 more source

Deep understanding of typical CNT morphology on the microstructure and mechanical properties of 2D carbon/carbon composites

Journal of Materiomics
For the inadequate interlaminar strength of 2D carbon/carbon (C/C) composite, in-situ grown carbon nanotubes (CNTs) reinforcing strategy was put forward to strengthen the interlaminar matrix at the nanoscale and inhibit the interlaminar cracking.
Jiajia Sun, Qiang Song, Liyuan Han, Xuemin Yin, Hejun Li   +4 more
doaj   +1 more source