Results 51 to 60 of about 470,253 (304)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Mixed modeling for fiber yield genetic selection in sugarcane

Revista de la Facultad de Ciencias Agrarias UNCuyo, 2021
The current demand for clean and renewable energy has provoked considerable changes in the production system of agroindustrial companies. The generation of bioelectricity through the burning of sugarcane bagasse has considerably risen in the recent years. This work aimed to focus on the sugarcane genotypes selection for fiber productivity.
João de Andrade Dutra Filho, Lauter Silva Souto, Rômulo Gil De Luna, Anielson dos Santos Souza, Frank Gomes Silva, Fabiana Aparecida Cavalcanti Silva, Djalma Euzébio Simões Neto, Tercilio Calsa Júnior   +7 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Unravelling seed oil, protein and fiber density in lintlessfuzzless upland cotton (Gossypium hirsutum. L) through combining ability estimates and association studies

Electronic Journal of Plant Breeding, 2023
An investigation was carried out to understand the gene action for seed oil, seed protein, seed gossypol, seed cotton yield and fiber density through intra-hirsutum crosses. Combining ability and gene action were studied in eighteen hybrids involving
L. Ananda Lekshmi1 , M. Kumar2*, S. Rajeswari3 , M. Raveendran4 , D. Uma5 and S. Manickam 6
doaj   +1 more source

Study of Some Factors Which Influence Froth Flotation of Deinked Stock [PDF]

, 1959
Mineral and fiber were concurrently reclaimed from coated waste stock with the froth flotation process. Percentages of ash and fiber reclaimed are included along with the brightness of the deinked stock.
Longjohn, Peter C.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Genetic analysis of yield and fiber quality traits in upland cotton (Gossypium hirsutum L.) cultivated in different ecological regions of China

Journal of Cotton Research, 2019
Background Cotton is an important fiber crop worldwide. The yield potential of current genotypes of cotton can be exploited through hybridization. However, to develop superior hybrids with high yield and fiber quality traits, information of genetic ...
Kashif SHAHZAD, Xue LI, Tingxiang QI, Liping GUO, Huini TANG, Xuexian ZHANG, Hailin WANG, Meng ZHANG, Bingbing ZHANG, Xiuqin QIAO, Chaozhu XING, Jianyong WU   +11 more
doaj   +1 more source