Results 91 to 100 of about 21,236,271 (159)

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice.

PLoS Genetics, 2015
Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils. Mutations in the gene for fibrillin-1 cause the Marfan syndrome, while mutations in the gene for fibrillin-2 cause ...
Gerhard Sengle, Valerie Carlberg, Sara F Tufa, Noe L Charbonneau, Silvia Smaldone, Eric J Carlson, Francesco Ramirez, Douglas R Keene, Lynn Y Sakai   +8 more
doaj   +1 more source

The hidden science of haptics: A pedagogical review of tactile evaluation in cosmetics

International Journal of Cosmetic Science, Volume 48, Issue 3, Page 600-634, June 2026.
This review explores the physiological basis of tactile perception and critically examines classical and emerging sensory methods used in cosmetics, advocating for broader methodological integration and recognition of sensory analysis in the field. Abstract Sensory analysis is a cornerstone of cosmetic development, yet remains underrepresented in peer ...
Morgane Postec, Daria Terescenco, Ecaterina Gore   +2 more
wiley   +1 more source

MALICoT: A pilot cross‐sectional study analyzing the effects of power training and age on endomysium content and fiber area in the soleus muscle of adult males

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract The cross‐sectional Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) examined effects of athletic exercise and age on endomysium content in human soleus muscle. Forty‐three clinically healthy male participants were grouped into young (20–35 years) nonphysically active controls (n = 12), young power ...
Christoph S. Clemen, Sebastian W. Humbsch, Carolin Berwanger, Leonid Mill, Andreas Schmidt, Rolf Schröder, Jörn Rittweger   +6 more
wiley   +1 more source

Synthesis of elastic microfibrillar components fibrillin-1 and fibrillin-2 by human optic nerve head astrocytes in situ and in vitro

, 2000
The purpose of this study was to identify elastic microfibrillar components fibrillin-1 and fibrillin-2 in optic nerve heads of adult normal and glaucomatous subjects.
Pena, JDO, Mello, PAA, Hernandez, M. R.
core   +1 more source

Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions

, 2008
Fibrillin-1 N- and C- terminal heparin binding sites have been characterized. An unprocessed monomeric N-terminal fragment (PF1) induced a very high heparin binding response, indicating heparin-mediated multimerization.
Baldwin, Andrew K., Kielty, Cay M., Jowitt, Thomas A, Shuttleworth, C Adrian, Cain, Stuart A.; id_orcid, Jowitt, Thomas A.; id_orcid, Cain, Stuart A, Couchman, John R., Couchman, John R, Mahalingam, Yashithra, Raynal, Bertrand, Kielty, Cay M, Shuttleworth, C. Adrian, Baldwin, Andrew K   +13 more
core   +1 more source

Systemic sclerosis sera affect fibrillin-1 deposition by dermal blood microvascular endothelial cells:therapeutic implications of cyclophosphamide [PDF]

, 2013
Introduction: Systemic sclerosis (SSc) is a connective tissue disorder characterized by endothelial cell injury, autoimmunity and fibrosis. The following three fibrillin-1 alterations have been reported in SSc.
Borghini, Annalisa, Matucci Cerinic, Marco, Manetti, Mirko, Nacci, Francesca, Sestini, Piersante, Ibba-Manneschi, Lidia, Villano, Marilisa, Weber, Elisabetta, Gabbrielli, Erica, Rossi, Antonella, Matucci-Cerinic, Marco, Ibba, Lidia, Guiducci, Serena, Milia, Anna F.   +13 more
core   +1 more source

Microfibrils and fibrillin-1 induce integrin-mediated signaling, proliferation and migration in human endothelial cells.

, 2010
International audienceMicrofibrils are macromolecular complexes associated with elastin to form elastic fibers that endow extensible tissues, such as arteries, lungs, and skin, with elasticity property. Fibrillin-1, the main component of microfibrils, is
Huber, Philippe, Cay Kielty, Gilles Faury, Mariko, Boubacar, Yves Usson, Philippe Huber, Kielty, Cay,, Ghandour, Zeinab, Zeinab Ghandour, Usson, Yves, Verdetti, Jean, Jean Verdetti, Quentin, Mickael, Stéphanie Raveaud, Faury, Gilles, Mickaël Quentin, Boubacar Mariko, Raveaud, Stephanie, Kielty, Cay, M.   +18 more
core   +1 more source

Cell Adhesion to Fibrillin-1 Molecules and Microfibrils Is Mediated by α5β1 and αvβ3 Integrins

, 2003
Fibrillins are the major glycoprotein components of microfibrils that form a template for tropoelastin during elastic fibrillogenesis. We have examined cell adhesion to assembled purified microfibrils, and its molecular basis.
Kielty, Cay M., Lomas, Amanda, Humphries, Jon, Morgan, Amanda, Bax, Daniel V., Bernard, Sarah E., Shuttleworth, C. Adrian, Humphries, Martin J.   +7 more
core   +1 more source

Compound heterozygous mutations in FBN1 in a large family with Marfan syndrome

Molecular Genetics & Genomic Medicine, 2020
Background Marfan syndrome (MFS) is a dominant monogenic disorder caused by mutations in fibrillin 1 (FBN1). Rarely, compound heterozygosity for FBN1 mutations has been described. Methods A large kindred with MFS was assessed clinically over decades, and
Aideen M. McInerney‐Leo, Jennifer West, Lawrie Wheeler, Paul J. Leo, Kim M. Summers, Lisa Anderson, Matthew A. Brown, Malcolm West, Emma L. Duncan   +8 more
doaj   +1 more source