Results 11 to 20 of about 21,236,271 (159)
Fibrillin-1: Organization in Microfibrils and Structural Properties
Journal of Molecular Biology, 1996 To investigate the microfibrillar organization and structural properties of fibrillin-1, we produced overlapping recombinant peptides in human cells which altogether span the fibrillin-1 molecule.
Dieter P Reinhardt +2 more
exaly +5 more sources
Cell adhesion and integrin binding to recombinant human fibrillin-1
FEBS Letters, 1996 Fibrillin-1 is a major constituent of tissue microfibrils that occur in most connective tissues, either in close association with or independent of elastin.
Dieter P Reinhardt +2 more
exaly +4 more sources
Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels? [PDF]
International Neurourology Journal, 2015 Purpose: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence.
Ayla Eser +8 more
doaj +2 more sources
Fibrillin-1 misfolding and disease.
Antioxidants & Redox Signaling, 2006 Fibrillin-1 is a 350 kDa calcium-binding protein which assembles to form 10-12 nm microfibrils in the extracellular matrix (ECM). The structure of fibrillin-1 is dominated by two types of disulfide-rich motifs, the calcium- binding epidermal growth ...
Hutchinson, S +3 more
core +4 more sources
Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development
Matrix Biology, 2002 The extracellular glycoproteins fibrillin-1 and fibrillin-2 are major components of connective tissue microfibrils. Mutations in the fibrillin-1 and fibrillin-2 genes are responsible for the phenotypical manifestations of Marfan syndrome and congenital ...
Fabio Quondamatteo +2 more
exaly +2 more sources
ADAMTSL-6 Is a Novel Extracellular Matrix Protein That Binds to Fibrillin-1 and Promotes Fibrillin-1 Fibril Formation [PDF]
Journal of Biological Chemistry, 2010 This research was originally published in the Journal of Biological Chemistry. Ko Tsutsui, Ri-ichiroh Manabe, Tomiko Yamada, Itsuko Nakano, Yasuko Oguri, Douglas R. Keene, Gerhard Sengle, Lynn Y. Sakai and Kiyotoshi Sekiguchi.
Manabe, Ri-ichiroh +8 more
core +5 more sources
Homotypic fibrillin-1 interactions in microfibril assembly [PDF]
Journal of Biological Chemistry, 2005 We have defined the homotypic interactions of fibrillin-1 to obtain new insights into microfibril assembly. Dose-dependent saturable high affinity binding was demonstrated between N-terminal fragments, between furin processed C-terminal fragments, and ...
Mellody, Kieran +8 more
core +4 more sources
Fibrillin-1 interactions with heparin: Implications for microfibril and elastic fiber assembly [PDF]
Journal of Biological Chemistry, 2005 Fibrillin-1 assembly into microfibrils and elastic fiber formation involves interactions with glycosaminoglycans. We have used BIAcore technology to investigate fibrillin-1 interactions with heparin and with heparin saccharides that are analogous to S ...
Gallagher, John +7 more
core +2 more sources
Fibrillin-3 expression in human development
Matrix Biology, 2011 Fibrillin proteins are the major components of extracellular microfibrils found in many connective tissues. Fibrillin-1 and fibrillin-2 are well studied and mutations in these proteins cause a number of fibrillinopathies including Marfan syndrome and ...
Laetitia Sabatier +2 more
exaly +2 more sources
Proteomic analysis of fibrillin-rich microfibrils
Proteomics, 2006 MS has been used to investigate the composition of fibrillin-rich microfibrils from non-elastic and elastic tissues, and to compare fibrillin-1 tryptic fingerprints derived from whole zonules, microfibrils and recombinant fibrillin-1.
Stuart A Cain +2 more
exaly +2 more sources