Results 181 to 190 of about 18,239 (220)

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. [PDF]

J Biol Chem, 2019
Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB.   +9 more
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Sex specific knee joint soft tissue mineralization with Fibrillin-1 mutation in male Tight Skin mice

Keenan C, Wang X, Dikmen T, Wen Y, Ramos-Mucci L, Shorter E, Abraham D, Bou-Gharios G, Poulet B.   +8 more
europepmc   +1 more source

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Immunohistochemical expression of fibrillin‐1 and fibrillin‐2 during tooth development

Journal of Periodontal Research, 2014
Background and ObjectiveOxytalan fibers are categorized as a microfibril assembly without elastin deposition, and are unique components in the periodontal ligament (PDL). However, little is known about their formation during PDL development. To clarify the mechanisms of oxytalan fiber formation in developing PDL, we performed immunohistochemical ...
M, Kira-Tatsuoka, K, Oka, E, Tsuruga, M, Ozaki, Y, Sawa   +4 more
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Non-Enzymatic Glycation of Human Fibrillin-1

Gerontology, 2008
Non-enzymatic glycation of proteins is one of the key mechanisms in the pathogenesis of diabetic complications and may be significant in the age-related changes of tissues. We isolated and investigated the in vitro glycation of human aortic fibrillin-1. Fibrillin-1 was prepared from thoracic aortas of 9 accident victims distributed in three age groups.
Milena, Atanasova, Emiliana, Konova, Tatiana, Betova, Stephan, Baydanoff   +3 more
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Defective Calcium Binding to Fibrillin-1: Consequence of an N2144S Change for Fibrillin-1 Structure and Function

Journal of Molecular Biology, 1999
Fibrillin-1 is a major structural component of 10-12 nm connective tissue microfibrils and has a modular organisation that includes 43 calcium binding epidermal growth factor-like (cbEGF) domains and seven transforming growth factor beta-binding protein-like (TB) domains.
S, Kettle, X, Yuan, G, Grundy, V, Knott, A K, Downing, P A, Handford   +5 more
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Fibrillin-1 im Bindegewebe

2017
Bindegewebe bezeichnet verschiedene Gewebetypen im Korper, die auf unterstutzende Aufgaben spezialisiert sind. Diese Gewebetypen enthalten relativ wenige Korperzellen sowie das biologische Material zwischen den Zellen, die so genannte extrazellulare Matrix.
Karina A. Zeyer, Dieter P. Reinhardt
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Gene Expression and Accumulation of Fibrillin-1, Fibrillin-2, and Tropoelastin in Cultured Periodontal Fibroblasts

Journal of Dental Research, 2002
The elastic system fibers consist of three types—oxytalan, elaunin, and elastic fibers—differing in their relative microfibril and elastin contents. All three types are found in human gingiva, but human periodontal ligaments contain only elastin-free fibers.
E, Tsuruga, K, Irie, T, Yajima
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Fibrillin-1 and asprosin, novel players in metabolic syndrome

Molecular Genetics and Metabolism, 2023
Fibrillin-1 is a major component of the extracellular microfibrils, where it interacts with other extracellular matrix proteins to provide elasticity to connective tissues, and regulates the bioavailability of TGFβ family members. A peptide consisting of the C-terminal 140 amino acids of fibrillin-1 has recently been identified as a glucogenic hormone,
Kim M, Summers, Stephen J, Bush, Margaret R, Davis, David A, Hume, Sahar, Keshvari, Jennifer A, West   +5 more
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Fibrillin-1: Organization in Microfibrils and Structural Properties

Journal of Molecular Biology, 1996
To investigate the microfibrillar organization and structural properties of fibrillin-1, we produced overlapping recombinant peptides in human cells which altogether span the fibrillin-1 molecule. The peptides were purified under non-denaturing conditions and extensive characterization indicated correct folding.
Reinhardt, Dieter P., Keene, Douglas R., Corson, Glen M., Pöschl, Ernst, Bächinger, Hans Peter, Gambee, Jay E., Sakai, Lynn Y.   +6 more
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Regulation of fibrillin-1 gene expression by Sp1

Gene, 2013
Mutations in the fibrillin-1 gene (FBN1) cause Marfan Syndrome (MFS), a hereditary disorder of connective tissue. The transcription of FBN1 has been reported to be driven by a short ultraconserved region (SUPR) in the 5' untranslated exon A of FBN1, but the nature of other factors involved in FBN1 gene regulation has not been clarified.
Gao, Guo, Christian, Rödelsperger, Martin, Digweed, Peter N, Robinson   +3 more
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