Results 191 to 200 of about 1,767,987 (273)

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

VIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi, Xipei Huang, Wutao Chen, Wen Di, Lin Huang, You Wang   +5 more
wiley   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Longitudinal changes in bleb morphology following the PAUL Glaucoma Implant visualized using ultrasonography

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate bleb morphology longitudinally using sonography following glaucoma drainage device (GDD) surgery. Methods Prospective observational cohort study conducted from January 2022 to March 2024, with follow‐up up to 12 months postoperatively. Bleb morphology, including superior and inferior bleb height, transverse and longitudinal
Constance Liegl, Benjamin Aretz, Leonie Bourauel, Pascal Schipper, Carolin Deubel, Lilli Joussen, Michael Petrak, Frank G. Holz, Raffael Liegl, Karl Mercieca   +9 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Development of a magnetic colloid for fibrin matrix dissolution

Les accidents vasculaires cérébraux (AVC) ischémiques représentent la majorité des AVC et constituent un enjeu majeur de santé publique. Leur traitement repose principalement sur la thrombolyse médicamenteuse, consistant à administrer un agent fibrinolytique (t-PA, plasmine) pour dissoudre le caillot responsable de l'occlusion.
openaire   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

3D‐Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair

Cell Proliferation, EarlyView.
3D printing transforms bioadhesives into structured, multifunctional interfaces that coordinate adhesion, mechanics, transport and biofunctional signalling and may thereby enable proliferative‐niche formation. Qualifying interfaces support cell survival, context‐appropriate proliferation and constructive remodelling advancing tissue repair towards ...
Zhen Gu, Xinyong Su, Guoshi Xu, Yongqiang Wen, Qi Gu   +4 more
wiley   +1 more source

Repositioning Non‐Ablative Fractional Lasers ‐ Molecular and Histological Insights from a scoping review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source

Soft fibrin matrix downregulates DAB2IP to promote Nanog-dependent growth of colon tumor-repopulating cells. [PDF]

Cell Death Dis, 2019
Zhang M, Xu C, Wang HZ, Peng YN, Li HO, Zhou YJ, Liu S, Wang F, Liu L, Chang Y, Zhao Q, Liu J.   +11 more
europepmc   +1 more source

Immune‐competent organ‐on‐chip methodologies to study type 1 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Type 1 diabetes (T1D) is a self‐driving autoimmune condition leading to the death of insulin‐producing β‐cells of the pancreas. β‐cell‐reactive immune cell extravasation into the intra‐islet space is fuelled by a cycle of inflammation including immune, vascular and endocrine dysfunction. Since clinical pancreatic biopsy is contraindicated,
Maja Witowska, Luigi Margiotta‐Casaluci, Periklis Pantazis, Margarita Dominguez‐Villar, Victoria Salem   +4 more
wiley   +1 more source