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Fibrin sealants: surgical hemostat, sealant and adhesive
Expert Opinion on Biological Therapy, 2014Fibrin sealants (FS) have been approved for use in the United States since 1998. Since approval, they have been used in a wide variety of clinical settings and new products continue to be introduced.This review covers the literature supporting the USA FDA-approved indications for FS products produced by Baxter Corp.
Samuel Mandell, Nicole Gibran
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Applications of Fibrin Sealant in Surgery
Surgical Innovation, 2005Fibrin sealant has been used with increasing frequency in a variety of surgical field for its unique hemostatic and adhesive abilities. Fibrin sealant mimics the last step of the coagulation cascade and takes place independently of the patient's coagulation status.
Meng-G Martin, Lee, Daniel, Jones
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A totally recombinant human fibrin sealant
Journal of Surgical Research, 2014Applications of plasma-derived human fibrin sealants (pdhFS) have been limited because of cost, limited supply of pathogen-screened plasma, the need for bioengineering improvements, and regulatory issues associated with federal approval. We describe a totally recombinant human fibrin sealant (rhFS), which may engender an abundant, safe, and cost ...
Iraklis Pipinos +2 more
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Current Opinion in Hematology, 1996
Fibrin sealant consists of fibrinogen and thrombin solutions, which generate a crosslinked fibrin clot in a process that mimics the last stage of the physiologic coagulation system. Fibrin sealants have been used widely in Europe in the past two decades for hemostasis, sealing, and as a vehicle for drugs and growth factors, and as a biologic glue. This
U, Martinowitz, R, Saltz
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Fibrin sealant consists of fibrinogen and thrombin solutions, which generate a crosslinked fibrin clot in a process that mimics the last stage of the physiologic coagulation system. Fibrin sealants have been used widely in Europe in the past two decades for hemostasis, sealing, and as a vehicle for drugs and growth factors, and as a biologic glue. This
U, Martinowitz, R, Saltz
openaire +4 more sources
Fibrin Sealants: Challenges and Solutions
ACS Biomaterials Science & Engineering, 2022Intraoperative bleeding and postoperative bleeding are major surgical complications. Tissue sealants, hemostats, and adhesives provide the armamentarium for establishing hemostatic balance, including the tissue sealant fibrin. Fibrin sealants combine advantages including instantaneous effect, biocompatibility, and biodegradability.
Matthias Beudert +3 more
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Fibrin Sealant for Fasciocutaneous Flaps
Journal of Reconstructive Microsurgery, 2010Fibrin sealant is used in many areas of surgery. We present a novel aspect of flap insetting in the ischial region using fibrin spray to seal the transferred tissue. We analyzed 10 patients suffering from decubital ulcers and assessed drainage output, time of drain removal, as well as complications following fasciocutaneous flap surgery.
Erba, Paolo +4 more
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Fibrin Sealant in Orthopedic Surgery
Clinical Orthopaedics and Related Research, 1988The use of clotting substances from blood for hemostasis dates back to 1909. In 1972, modern fibrin sealing (FS) was developed in Vienna. For application, the two components, i.e., a sealer protein solution (mainly fibrinogen) and a thrombin solution, are mixed to produce the fibrin clot.
G, Schlag, H, Redl
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Journal of Cardiac Surgery, 2003
Fibrin sealants and fibrin glues have become effective instruments in the care of surgical patients. They have been used as an adjunct to hemostasis, wound healing, tissue adhesion, and drug delivery. In cardiac surgery, fibrin glues have emerged as valuable tools to improve hemostasis, decreased blood transfusions, improve tissue handling, and ...
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Fibrin sealants and fibrin glues have become effective instruments in the care of surgical patients. They have been used as an adjunct to hemostasis, wound healing, tissue adhesion, and drug delivery. In cardiac surgery, fibrin glues have emerged as valuable tools to improve hemostasis, decreased blood transfusions, improve tissue handling, and ...
openaire +2 more sources