Results 191 to 200 of about 54,380 (300)

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang   +9 more
wiley   +1 more source

A high‐throughput bone marrow 3D co‐culture system to study resistance to BCR signalling targeted agents in B‐NHL

open access: yesBritish Journal of Haematology, EarlyView.
Bone marrow (BM) involvement in B‐cell non‐Hodgkin lymphoma (B‐NHL) is associated with poor prognosis, as the BM microenvironment provides a protective niche that promotes therapeutic resistance. We developed a simplified, automated and high‐throughput 3D BM co‐culture model that faithfully reproduces key tumour–stroma interactions.
Alex Zadro   +12 more
wiley   +1 more source

Meflin/ISLR is a meningeal cell‐specific marker involved in the development of meninges and meningioma progression

open access: yesBrain Pathology, EarlyView.
Mesenchymal stromal cell‐and fibroblast‐expressing Linx paralogue (Meflin) is expressed in embryonic meninges and contributes to meningeal homeostasis. In meningiomas, elevated Meflin correlates with higher grade and recurrence. Single‐cell RNA sequencing revealed a Meflin‐high tumor cell subset marked by reduced proliferation, WNT6 expression, and ...
Yukihiro Shiraki   +13 more
wiley   +1 more source

One‐Year Analysis of Clinical and Radiological Outcomes of Two‐Piece Zirconia Compared to Titanium Implants: A Multicenter Prospective Randomized Clinical Trial

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To evaluate the clinical performance of two‐piece zirconia implants with screw‐retained abutments compared to titanium implants after 1 year of loading. Materials and Methods In this multicenter, prospective, randomized clinical trial, 61 two‐piece zirconia and 61 titanium implants were placed and restored with single crowns ...
Marc Balmer   +5 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

open access: yesCell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie   +10 more
wiley   +1 more source

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