Results 51 to 60 of about 30,755 (186)

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

An Analysis of CT‐Guided Percutaneous Core Needle Biopsy of Tibial Lesions: How Successful Are We?

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Core needle biopsy (CNB) is commonly used to diagnose bone tumors, but characteristics of tibial lesions may affect its diagnostic performance. We evaluated the diagnostic performance of CT‐guided CNB for tibial lesions, factors associated with diagnostic success, and outcomes of nondiagnostic biopsies.
Lauren E. Wessel, Mikayla R. Mefford, Durga Ghosh, Scott D. Nelson, Alexander B. Christ, Michael Russell, Nicholas M. Bernthal, Joseph K. Kendal   +7 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Fibro-osseous lesion of maxilla. Report of two cases in a family with review of literature [PDF]

, 2011
Fibrous dysplasia is a disturbance of bone metabolism that is classified as a benign fibro-osseous lesion. Fibrous connective tissue containing abnormal bone, replaces normal bone. The etiology of fibrous dysplasia is unknown.
S. Sheikh, Sheikh, Soheyl, P. Shambulingappa, Kaur, Bhawandeep, B. Kaur, Shambulingappa, P.   +5 more
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Case report: Giant ossifying fibroma of the mandible

South Sudan Medical Journal, 2022
Ossifying fibroma is classified as a benign bone tumour. It is often considered to be a type of fibro-osseous lesion. It can affect both the mandible and the maxilla, particularly the mandible. This bone tumour consists of highly cellular, fibrous tissue
Ernesto Carmona Fernández
doaj   +1 more source

Genetic determinants of fibro-osseous lesions in aged inbred mice.

, 2016
Fibro-osseous lesions in mice are progressive aging changes in which the bone marrow is replaced to various degrees by fibrovascular stroma and bony trabeculae in a wide variety of bones.
Cates, Justin M, Silva, Kathleen A, Kennedy, Victoria E, Berndt, Annerose, Schofield, Paul N, Sundberg, John P, Sundberg, Beth A, Ackert-Bicknell, Cheryl   +7 more
core   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Fibro-osseous lesions of the craniofacial bones: β-catenin immunohistochemical analysis and CTNNB1 and APC mutation analysis. [PDF]

, 2014
The canonical Wnt/β-catenin pathway is involved in the formation of craniofacial skeleton and oral tissues. Aberrant nuclear localization of β-catenin protein has been described in several human diseases including a subset of odontogenic tumors thereby ...
E Horvai, Andrew, C Jordan, Richard
core   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source