Results 201 to 210 of about 94,496 (352)

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Antibody-drug conjugates in cancer and beyond: progress, promise, and perspectives. [PDF]

Antib Ther
Goldmacher VS.
europepmc   +1 more source

Effects of plasma fibronectin on chemiluminescence of human polymorphonuclear leukocytes

, 1984
Masayasu Iwase, Makoto Yoshiya, Shinya Ito, Yoshitaka Kimura, Masao Nagumo   +4 more
openalex   +2 more sources

Lipopolysaccharide-Activated Macrophages Stimulate the Synthesis of Collagen Type I and C-Fibronectin in Cultured Pancreatic Stellate Cells [PDF]

, 1999
Alexandra Schmid‐Kotsas, Hans‐Jürgen Groß, André Menke, H Weidenbach, Guido Adler, Marco Siech, Hans G. Beger, A. Grünert, Max G. Bachem   +8 more
openalex   +1 more source

The oncofetal domain of fibronectin defined by monoclonal antibody FDC-6: its presence in fibronectins from fetal and tumor tissues and its absence in those from normal adult tissues and plasma.

Proceedings of the National Academy of Sciences of the United States of America, 1985
H. Matsuura, S. Hakomori
semanticscholar   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Utilizing Engineered Monobodies for the Electrochemical Quantification of Lysozyme. [PDF]

Anal Chem
Dey S, Naser A, Woldring DR, Hickey DP.
europepmc   +1 more source

Plasma fibronectin in patients with chronic active hepatitis and cirrhosis of the liver with signs of disseminated intravascular blood coagulation syndrome

, 1993
Б. Н. Левитан, А. В. Астахин, P. P. Proshina   +2 more
openalex   +1 more source

Isolation and characterization of cDNA clones for human and bovine fibronectins.

Proceedings of the National Academy of Sciences of the United States of America, 1983
A. Kornblihtt, K. Vibe-Pedersen, F. Baralle   +2 more
semanticscholar   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source