Results 181 to 190 of about 952,925 (309)

Collagen-producing eye cell atlas reveals distinct fibroblast fates in early injury vs. fibrotic subretinal disease. [PDF]

Proc Natl Acad Sci U S A
Ozaki E, Aktas S, Mulfaul K, Brennan K, Roubeix C, Palko S, Robb K, Ou Yang TH, Schanne-Klein MC, Toidze A, Watson A, Cahill M, Westenskow PD, Feenstra D, Doyle SL.   +14 more
europepmc   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration. [PDF]

J Cachexia Sarcopenia Muscle
Epis R, Rovetta G, Ferrari G, Bonfanti C, Careccia G, Messina G.   +5 more
europepmc   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Endothelial cell-specific knockout of ATG5 ameliorates inflammation and renal fibrosis by regulating pyroptosis. [PDF]

Inflamm Res
Huang Y, Wen S, Chen L, Gao Y, Xu S, Fang C, Tang J, Yuan Y, Feng Y, Ma S, Luo S, Zhang Q, Shi X, Ruan X, Guo X.   +14 more
europepmc   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

The TREM2 paradox in fibrosis: a unified mechanism for opposite outcomes across organs. [PDF]

Front Immunol
Liang X, Li Y, Tang Z, Wang G, Liu Y.
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Cytomegalovirus-associated pulmonary exacerbation in patients with cystic fibrosis

ERJ Open Research, 2018
Akhil Sawant, Giulia Spoletini, Paul Whitaker, Christine Etherington, Ian Clifton, Daniel Peckham   +5 more
doaj   +1 more source

Advances in the Targeted Drug Delivery System for Renal Fibrosis. [PDF]

Int J Nanomedicine
Zheng YY, Hao JF, Liu JY, Wang SY, Mu XD, Jiang HL, He YJ.   +6 more
europepmc   +1 more source