Results 41 to 50 of about 338,760 (261)

ECHO: enhanced communication for hearing impaired in online video podcasts

open access: yesDiscover Data
We present a system for hearing-impaired people, designed to enhance the accessibility of video podcasts by identifying and displaying the current speaker. Current methods often focus on either audio–visual integration or speech transcription to identify
Gouthami Godhala   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

A novel robust method for estimating the covariance matrix of financial returns with applications to risk management

open access: yesFinancial Innovation
This study introduces the dynamic Gerber model (DGC) and evaluates its performance in the prediction of Value at Risk (VaR) and Expected Shortfall (ES) compared to alternative parametric, non-parametric and semi-parametric methods for estimating the ...
Arturo Leccadito   +2 more
doaj   +1 more source

Demographic consequences of translocation of overabundant Canada geese breeding in urban areas

open access: yesWildlife Society Bulletin, 2017
Translocation is a common tool for managing nuisance Canada geese (Branta canadensis) in urban areas across North America. However, no previous research has assessed how translocation affects survival and philopatry at donor and release sites.
D. T. Tyler Flockhart, Jared B. Clarke
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Communication without communication [PDF]

open access: yesZbornik Radova Filozofskog Fakulteta u Prištini, 2017
This paper analyses the necessary conditions for successful communication. It is well known that post-modernity, described as an era of control, produces only decentralized, imploded subjectivities, who are neither able to question their own being nor to
Bratina Boris R., Knëževič Višnja D.
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Paul Revisited: A Constellation of Alain Badiou’s Discernments on Saint Paul

open access: yesReligions
This study aims to contribute to the ongoing Pauline discourse by presenting Alain Badiou’s infusion of his own thinking of event theory into Pauline thinking of Jesus’ Resurrection and explores a constellation of Alain Badiou’s conceptualization and ...
Murat Kadiroglu, Adnan Akan
doaj   +1 more source

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