Results 81 to 90 of about 533,902 (337)

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human haematopoietic stem and progenitor cells

Nature Medicine, 2018
Translation of the CRISPR–Cas9 system to human therapeutics holds high promise. However, specificity remains a concern especially when modifying stem cell populations.
Christopher A. Vakulskas, D. Dever, G. Rettig, R. Turk, Ashley M. Jacobi, Michael A. Collingwood, Nicole M. Bode, Matthew S. McNeill, Shuqi Yan, J. Camarena, Ciaran M. Lee, S. H. Park, V. Wiebking, R. Bak, N. Gomez-Ospina, Mara Pavel-Dinu, Wenchao Sun, Gang Bao, M. Porteus, M. Behlke   +19 more
semanticscholar   +1 more source

Cognitive Behavioral Therapy for Youth with Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, Accepted Article.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Top 10 Essential Data Science Topics to Real-World Application from the Industry Perspectives

Harvard Data Science Review, 2021
Victor S.Y. Lo
doaj   +1 more source

Development and Preliminary In Vivo Study of 3D‐Printed Bioactive Glass Scaffolds with Trabecular Architecture

Advanced Engineering Materials, EarlyView.
This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov, Roberta Gabrieli, Avzal Akbarov, Nigora Nigmatova, Bekhzod Khabilov, Alessandro Schiavi, Martin Schwentenwein, Enrica Verné, Francesco Baino   +8 more
wiley   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Transfer Printing of Ordered Plasmonic Nanoparticles at Hard and Soft Interfaces with Increased Fidelity and Biocompatibility Supports a Surface Lattice Resonance [PDF]

, 2023
Keith R. Berry, D. Keith Roper, Michelle A. Dopp, John C. Moore   +3 more
openalex   +1 more source

Hybrid Auxetic Architectures: Integrating Curvature‐Driven Design for Enhanced Mechanical Tunability and Structural Performance

Advanced Engineering Materials, EarlyView.
Curvature‐tuned auxetic lattices are designed, fabricated, and mechanically characterized to reveal how geometric curvature governs stretchability, stress redistribution, and Poisson's ratio evolution. Photoelastic experiments visualize stress pathways, while hyperelastic simulations quantify deformation mechanics.
Shuvodeep De, Giovanni Meli, Meysam Khalighian, Anahita Emami   +3 more
wiley   +1 more source

Design and Prototyping of Topology‐Optimized, Additively Manufactured Lightweight Components for Space Robotic Systems: A Case Study

Advanced Engineering Materials, EarlyView.
The results demonstrate a simulation‐driven workflow that applies LSB topology optimization with additive manufacturing constraints to mission‐specific load cases, integrating European Cooperation for Space Standardization compliant verification and manufacturability to develop structurally efficient rover suspension components.
Stelios K. Georgantzinos, Grigorios Kostopoulos, Eleni Papadopoulou, Stefanos Voulgaris, Alexandra Tseni, Panteleimon Bakalis, Maria N. Gkara, Chara Ch. Mitropoulou, Georgios Kazakis, Alin Munteanu, Jeremi Gancet, Nikos D. Lagaros   +11 more
wiley   +1 more source

Level of Implementation Fidelity of Youth-Friendly Services in Northwest Ethiopia

Risk Management and Healthcare Policy, 2021
Yohannes Ayanaw Habitu,1 Gashaw Andargie Biks,2 Abebaw Gebeyehu Worku,1 Kassahun Alemu Gelaye3 1Department of Reproductive Health, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of
Habitu YA, Biks GA, Worku AG, Gelaye KA
doaj