Results 91 to 100 of about 5,931,505 (319)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Increasing expansion of large-scale crop production onto deforested land in sub-Andean South America
Environmental Research Letters, 2018 A combination of high commodity crop prices, rising global food demand, and technological advances has transformed the scale of global crop production.
Jordan Graesser +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
On squares in special sets of finite fields [PDF]
, 2016 Mikhail R. Gabdullin
openalex +1 more source
A keen collector and sketcher of plant specimens from an early age, the author, educator and clergyman Charles Alexander Johns (1811–74) gained recognition for his popular books on British plants, trees, birds and countryside walks. The Forest Trees of Britain (1847–9), one of several works originally published by the Society for Promoting Christian ...
openaire +7 more sources
Fields of The World: A Field Guide for Extracting Agricultural Field Boundaries
CoRRField boundary maps are a building block for agricultural data products and support crop monitoring, yield estimation, and disease estimation. This tutorial presents the Fields of The World (FTW) ecosystem: a benchmark of 1.6M field polygons across 24 countries, pre-trained segmentation models, and command-line inference tools. We provide two notebooks
Isaac Corley +3 more
openaire +2 more sources