Results 121 to 130 of about 515,526 (309)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Field enhancement induced laser ablation

, 2011
Sub-diffraction spatially resolved, quantitative mapping of strongly localized field intensity enhancement on gold nanostructures via laser ablation of polymer thin films is reported.
Fiutowski, Jacek; id_orcid, Maibohm, Christian, Rubahn, Horst-Günter; id_orcid, Kjelstrup-Hansen, Jakob; id_orcid   +3 more
core   +1 more source

Cascade hydropower-induced land use change reshapes sources and ecological risks of soil heavy metals in Wudongde Reservoir resettlement zones

Ecotoxicology and Environmental Safety
Cascade hydropower reshapes land use and interactions in reservoir regions, potentially altering soil heavy metal risks. Eight metals (As, Cd, Cr, Cu, Hg, Ni, Pb, Zn) were quantified in 20 surface soils from the head, middle and tail resettlement zones ...
Qiang Li, Wangtao Yang, Peiyuan Yu, Mengyun Li, Chengzhong He, Ya Zhang, Jiazhong Huang, Yanping Xue, Danqing Liao, Liankai Zhang, Mingguo Lan   +10 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nanoplasmonic surfaces enabling strong surface-normal electric field enhancement

, 2013
Conventional two-dimensional (2D) plasmonic arrays provide electric field intensity enhancement in the plane, typically with a surface coverage around 50% in the plan-view.
Demir, Hilmi Volkan, Gungor, K., Unal, E.   +2 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Field emission enhancement by the quantum structure in an ultrathin multilayer planar cold cathode

, 2008
Field electron emission (FE) from an ultrathin multilayer planar cold cathode (UMPC) including a quantum well structure has been both experimentally and theoretically investigated.
hyan@bjut.edu.cn, Zhang, XW, Yan, H, Wang, RZ, Wang, RZ, Beijing Univ Technol, Lab Thin Flim Mat, Coll Mat Sci & Engn, Beijing 100022, Peoples R China. 电子邮箱地址: wrz@bjut.edu.cn, Wang, B, Hou, XY   +6 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

High-density field-based 3D reconstruction of rice architecture across diverse cultivars for genome-wide association studies

Plant Methods
Background Rice plant architecture underpins yield and grain quality, yet two obstacles impede accurate field characterization in dense paddies. First, single-plant reconstruction is constrained by severe inter-plant occlusion, cluttered backgrounds, and
Jiexiong Xu, Jiyoung Lee, Xiangchao Gan
doaj   +1 more source

Electromagnetic-field-induced cohesive force enhancement in a metallic nanowire

, 2004
We theoretically study the conducting electronic contribution to the cohesive force in a metallic nanowire irradiated under a transversely polarized external electromagnetic field at low temperatures and in the ballistic regime.
Xiao, XB, Zhou, GH, Hunan Normal Univ, Dept Phys, Changsha 410081, Peoples R China. 电子邮箱地址: ghzhou@hunnu.edu.cn, Yang, M, Li, Y, Zhou, GH   +4 more
core