By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
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We examine the effect of an external guide field and current sheet thickness on the growth rates and nature of three dimensional unstable modes of an electron current sheet driven by electron shear flow.
Büchner, Jörg, Jain, Neeraj
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Caterpillars of Eastern Forests. David L. Wagner, Valerie Giles, Richard C. Reardon and Michael L. McManus. 1997. USDA Forest Service FHTET-96-34, 113 pp., soft cover. [PDF]
(excerpt) Over the years, I have lamented the lack of a popular guide to Lepidoptera larvae. Aside from the classic Golden Guide to Butterflies and Moths (R.T. Mitchell and H. S. Zim, 1987.
O\u27Brien, Mark F
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Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
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Field guide to trees of Southern Africa
The mainland region of Africa is Southern Africa because it is considered to be robust with an estimate of around 1700 tree species that are native and a couple 100 more that are alien, but have become accustomed to the natural environment; invading ...
Rishan Singh
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Water and Development Strategy: Implementation Field Guide [PDF]
This document is intended to serve as a reference tool to help USAID Operating Units understand and apply the agency's 2013-2018 Water and Development Strategy. By publicly sharing the document, USAID aims to ensure coordination of their efforts with the
core
Parallel electric fields are inefficient drivers of energetic electrons in magnetic reconnection
We present two-dimensional kinetic simulations, with a broad range of initial guide fields, that isolate the role of parallel electric fields ($E_\parallel$) in energetic electron production during collisionless magnetic reconnection. In the strong guide
Dahlin, J. T., Drake, J. F., Swisdak, M.
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
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