Results 41 to 50 of about 18,172 (288)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The study of literary topoi as an area of comparative literature: the case of “murder for love”
Philologia Hispalensis, 2022 This article aims to examine the position of literary topoi in the field of comparative literature using Escobar (2000) and Laguna Mariscal’s (1999) definition of topoi.
Zahra Nazemi
doaj +1 more source
Desecration of the history as a method of literary processing of the historical field of events
Current issues of social sciences and history of medicine, 2017 This article will focus on the environment of the generation of the eighties, in particular, about the aesthetic, thematic, genre features of small prose and its connection with the Ukrainian novel. The problem of the plot interpretation, the novelistic scheme of the Western canon and the East Slavic pattern in the creative Twentieth Century brought a ...
openaire +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Entre a história cultural e a teoria literária: rumo a uma história dos cânones escolares no Brasil
Revista Brasileira de História da Educação, 2012 Foi com o intuito de localizar e discutir os momentos em que Chartier dialoga com os (ou se apropria dos) estudos literários, em alguns de seus textos e entrevistas, bem como de verificar o modo como o autor sugere uma linha de pesquisas que cruza ...
Luiz Eduardo M. de Oliveira
doaj +2 more sources
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Writing Manuals for the Masses [PDF]
, 2021 This open access collection of essays examines the literary advice industry since its emergence in Anglo-American literary culture in the mid-nineteenth century within the context of the professionalization of the literary field and the continued debate ...
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source