Results 81 to 90 of about 12,213,158 (301)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Review: Roland Girtler (2004). 10 Gebote der Feldforschung [The Ten Commandments of Field Study]

Forum: Qualitative Social Research, 2005
The experienced ethnographer ROLAND GIRTLER gives ten important "commandments" in his book for field research. Using personal observation and ero-epic dialogue, GIRTLER explores the possibilities of research into different life environments of our time ...
Martin Spetsmann-Kunkel
doaj  

Contextualizing phenomenology in event management research: Deciphering the meaning of event experiences [PDF]

, 2013
Purpose - Although the core phenomenon of events is the experiences and the meanings attached to them, there is limited management research on the experiential, existential and ontological dimensions of events.
Boukas, N, Ziakas, V
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Traditionally utilization of Selaginella; field research and literature review [PDF]

, 2009
Penelitian ini bertujuan untuk mengetahui manfaat Selaginella dalam pengobatan tradisional dan pemanfaatan lainnya, melalui penelitian lapangan dan telaah pustaka, khususnya di Jawa dan Kepulauan Nusantara. Sebanyak 200 dari 700-750 spesies Selaginella
SETYAWAN, AHMAD DWI
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Recordings of traditional music from the archive of the institute of Musicology SASA as the sources for history of the folk culture of Kosovo and Metohija region [PDF]

Baština, 2018
this study represents almost unknown sound sources - recordings of traditional music from the 1950s and 1960s, made on the territory of Kosovo and Metohija region by Miica Ilijin and Dr Radmila Petrović, fellows of the Institute of Musicology of the ...
Mihajlović-Lajić Danka R., Jovanović Jelena Lj.   +1 more
doaj  

Traditionaly utilization of Selaginella; field research and literature review [PDF]

, 2009
Setyawan AD. 2009. Traditionaly utilization of Selaginella; field research and literature review. Nusantara Bioscience 1: 146-154. The aims of this research were to find out traditional usage of Selaginella in medication and its other usages ...
SETYAWAN, AHMAD DWI
core