Results 91 to 100 of about 698,120 (289)

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Critical exponents from optimised renormalisation group flows [PDF]

, 2002
Within the exact renormalisation group, the scaling solutions for O(N) symmetric scalar field theories are studied to leading order in the derivative expansion. The Gaussian fixed point is examined for d>2 dimensions and arbitrary infrared regularisation.
Aoki, Bagnuls, Ball, Bergerhoff, Bergerhoff, Bergerhoff, Berges, Bohr, Bonanno, Comellas, Daniel F. Litim, Ellwanger, Ellwanger, Freire, Golner, Hasenfratz, Lauscher, Lauscher, Liao, Liao, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Margaritis, Mazza, Morris, Morris, Morris, Morris, Polchinski, Reuter, Reuter, Tetradis, Tetradis, Von Gersdorff, Wetterich, Wetterich, Zinn-Justin   +47 more
core   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

E 8 instantons on type-A ALE spaces and supersymmetric field theories

Journal of High Energy Physics, 2017
We consider the 6d superconformal field theory realized on M5-branes probing the E 8 end-of-the-world brane on the deformed and resolved ℂ 2/ℤ k singularity.
Noppadol Mekareeya, Kantaro Ohmori, Yuji Tachikawa, Gabi Zafrir   +3 more
doaj   +1 more source

Bootstrapping $O(N)$ Vector Models in $4

, 2015
We use the conformal bootstrap to study conformal field theories with $O(N)$ global symmetry in $d=5$ and $d=5.95$ spacetime dimensions that have a scalar operator $\phi_i$ transforming as an $O(N)$ vector.
Chester, Shai M., Pufu, Silviu S., Yacoby, Ran   +2 more
core   +1 more source

Abelian-Projected Effective Gauge Theory of QCD with Asymptotic Freedom and Quark Confinement [PDF]

, 1997
Starting from SU(2) Yang-Mills theory in 3+1 dimensions, we prove that the abelian-projected effective gauge theories are written in terms of the maximal abelian gauge field and the dual abelian gauge field interacting with monopole current.
A. Hart, A. Kronfeld, A. Kronfeld, A.M. Polyakov, C.G. Callan, Jr., C.G. Callan, Jr., D. Zwanziger, D.I. Dyakonov, D.I. Dyakonov, F. Fucito, G. ’t Hooft, G. ’t Hooft, H. Hata, H. Levine, H. Min, H. Shiba, H. Suganuma, H. Suganuma, H.B. Nielsen, J. Fröhlich, J. Smit, J. Smit, K. Bardakci, K. Bardakci, K.-I. Kondo, K.-I. Kondo, K.G. Wilson, K.G. Wilson, Kei-Ichi Kondo, L. Del Debbio, M. Baker, M. Feurstein, M. Fukushima, M. Martellini, M. Stone, M.B. Halpern, M.I. Polikarpov, M.N. Chernodub, N. Seiberg, N. Seiberg, O. Miyamura, P.A.M. Dirac, P.A.M. Dirac, R. Rajaraman, R.A. Brandt, R.C. Brower, S. Hioki, S. Hioki, S. Kitahara, S. Maedan, S. Mandelstam, S. Raby, S. Sasaki, S.V. Shabanov, T. Banks, T. Kugo, T. Suzuki, T. Suzuki, T. Suzuki, T.A. DeGrand, T.T. Wu, T.T. Wu, V. Bornyakov, Y. Nambu, Z.F. Ezawa, Z.F. Ezawa   +65 more
core   +3 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Discrete gauging in six dimensions

Journal of High Energy Physics, 2018
When n M5 branes coincide on an A type singularity, ℂ2 /ℤ k , there is a multitude of tensionless strings which arise in the spectrum. The low energy theory when all M5 branes are separated at the singularity is given by a linear quiver with parameters n
Amihay Hanany, Gabi Zafrir
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Computing Yukawa Couplings from Magnetized Extra Dimensions

, 2004
We compute Yukawa couplings involving chiral matter fields in toroidal compactifications of higher dimensional super-Yang-Mills theory with magnetic fluxes. Specifically we focus on toroidal compactifications of D=10 super-Yang-Mills theory, which may be
, A. Brignole, A. Gonzalez-Arroyo, A. Polishchuk, A. Strominger, A.M. Uranga, B. Acharya, C. Angelantonj, C. Bachas, C. Csáki, D Cremades, D. Cremades, D. Cremades, D. Cremades, D. Cremades, D. Lüst, D. Mumford, F Marchesano, F. Feruglio, G. 't Hooft, G. Aldazabal, G. Aldazabal, G. Aldazabal, G. Honecker, G. Honecker, G. Honecker, G. Honecker, I. Brunner, J. Erdmenger, J.F.G. Cascales, L.E Ibanez, L.E. Ibáñez, L.E. Ibáñez, M. Aganagic, M. Aganagic, M. Cvetic, M. Cvetic, M. Marino, M.B. Green, M.R. Douglas, M.R. Douglas, M.R. Douglas, M.R. Douglas, N. Arkani-Hamed, P. Griffiths, P. van Baal, P. van Baal, R. Blumenhagen, R. Blumenhagen, R. Blumenhagen, R. Blumenhagen, R. Blumenhagen, R. Blumenhagen, R. Blumenhagen, S. Kachru, S. Kachru, T.P.T. Dijkstra   +56 more
core   +1 more source