Results 161 to 170 of about 9,510,506 (294)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Assessing the Sterile Insect Technique in Small, Non-Isolated Urban Areas: A Field Trial Against <i>Aedes albopictus</i> in Southern Switzerland. [PDF]

Insects
Parrondo Monton D, Ravasi D, Anicic N, Lettieri M, Storelli P, Puggioli A, Trisconi N, Tanadini M, Flacio E.   +8 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Field Trial Demonstrates Superiority of a Live Attenuated Vaccine for Integrated Control of <i>Mycoplasmal pneumonia</i> of Swine and Improved Production Performance in Commercial Swine Farms. [PDF]

Animals (Basel)
Lin C, Xiang Y, Jiang J, Zhang Y, Wang H, He J.   +5 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Evaluation of Trap Systems for Monitoring of Odontothrips loti and Frankliniella occidentalis: A Pilot Field Trial. [PDF]

Insects
Luo Y, Han C, Tu X, McNeill MR, Yin X, Ban L.   +5 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

A double-blinded, placebo-controlled field trial of an OspA-based oral reservoir targeted vaccine against Borrelia burgdorferi. [PDF]

NPJ Vaccines
Schwartz AM, Henao-Ceballos F, Arnold K, Poje J, Waugh M, Joyner G, Azevedo JF, Baccam T, Kontowicz E, Mahachi K, Witucki P, Kundu S, Nair N, Pabon-Rodriguez F, Brown G, Maryland Field Team, Petersen C, Gomes-Solecki M.   +17 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Detect and Trace: An Australian Field Trial Using Machine-Learning Tools to Combat Illegal Wildlife Trade. [PDF]

Animals (Basel)
Meagher P, Cincotta J, Phan HTH, Shen K, Dolman B, Brandis KJ, Pelliccia D, Poole CM, Vinette Herrin K, O'Brien JK, Allman BE, Mazumder D, Gadd PS, Pirotta V.   +13 more
europepmc   +1 more source