Results 11 to 20 of about 230,200 (216)

From home to the streets: Can cultural socialization foster Latinx youths' social responsibility?

open access: yesAmerican Journal of Community Psychology, Volume 70, Issue 3-4, Page 278-290, December 2022., 2022
Abstract Grassroots movements such as Poder Quince exemplify how Latinx youth intertwine their cultural heritage and traditions with civic action to create positive change within their communities. Parents' cultural socialization messages have been shown to instill cultural pride and encourage prosocial behaviors (e.g., helping others, caring for ...
Saraí Blanco Martinez   +2 more
wiley   +1 more source

Two SOX11 variants cause Coffin–Siris syndrome with a new feature of sensorineural hearing loss

open access: yesAmerican Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 183-189, January 2023., 2023
Abstract Coffin‐Siris syndrome (CSS, OMIM#135900) is a rare congenital disorder associated with neurodevelopmental and dysmorphic features. The primary cause of CSS is pathogenic variants in any of 9 BAF chromatin‐remodeling complex encoding genes or the genes SOX11 and PHF6. Herein, we performed whole‐exome sequencing (WES) and a series of analyses of
Qiuquan Wang   +5 more
wiley   +1 more source

Altruism in death: Attitudes to body and organ donation in Australian students

open access: yesAnatomical Sciences Education, Volume 16, Issue 1, Page 27-46, January/February 2023., 2023
Abstract Health education, research, and training rely on the altruistic act of body donation for the supply of cadavers. Organ transplantation and research rely on donated organs. Supply of both is limited, with further restrictions in Australia due to requirements for a next‐of‐kin agreement to donation, irrespective of the deceased's pre‐death ...
Rebekah A. Jenkin   +2 more
wiley   +1 more source

Effects of greenwashing on financial performance: Moderation through local environmental regulation and media coverage

open access: yesBusiness Strategy and the Environment, Volume 32, Issue 1, Page 820-841, January 2023., 2023
Abstract Recent research suggests that the effect of greenwashing and corporate financial performance (CFP) is ambiguous. This call for study the contextual factors that create contingencies in the greenwashing–CFP relationship. Using a sample of 2816 observations covering 735 Chinese‐listed firms in 21 different industries from 2013 to 2017, this ...
Wei Li   +3 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Structural Insights Into Aluminum‐Doped Manganese Dioxides as Promising Materials for Direct Lithium Extraction: Modeling and Mechanism Study

open access: yesAdvanced Materials Interfaces, EarlyView.
A two‐stage sorption mechanism is proposed for Al‐doped HMnO in direct lithium extraction. Batch sorption experiments and modeling identify two key sorption sites on Al‐HMnO: surface sites (planar and edge) and vacancy sites (W). At pH 12, Stage I involves surface ion exchange, followed by Stage II, where surface complexation occurs between Li⁺ ions ...
Shuxuan Yan   +6 more
wiley   +1 more source

How and when does personal life orientation predict well‐being?

open access: yesThe Career Development Quarterly, Volume 70, Issue 4, Page 240-255, December 2022., 2022
Abstract We examined the direct and indirect––as mediated by job satisfaction––effects of personal life orientation on life satisfaction. We also examined whether these direct and indirect associations differed between employees working onsite or remotely. Using data from 432 employees (152 working onsite and 280 working remotely), our results revealed
Nicolas Gillet   +4 more
wiley   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang   +4 more
wiley   +1 more source

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

open access: yesAdvanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu   +10 more
wiley   +1 more source

Treatment‐related adverse events of antibody–drug conjugates in clinical trials: A systematic review and meta‐analysis

open access: yesCancer, Volume 129, Issue 2, Page 283-295, 15 January 2023., 2023
Abstract Background Antibody–drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance. Methods In a systematic review and meta‐analysis of data gathered from different scientific databases ...
Youwen Zhu   +3 more
wiley   +1 more source

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