Results 121 to 130 of about 85,792 (305)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

COLOSSUS - Collaborative System of Systems Exploration of Aviation Products, Services and Business Models

, 2023
COLOSSUS paves the way for future European aviation products and services which are designed in a truly holistic approach and to thus provide a major contribution to the digital transformation of aviation and air transportation in order to enable ...
Cusati V., Nicolosi F., De Marco A., Della Vecchia P., Tuccillo M.   +4 more
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An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The awareness among secondary boarding school student about fire fighting system at school

, 2013
Fire may occur in the building when a heat source comes in contact with a combustible material in the presence of oxygen, sometimes as quickly as within minutes.Therefore, the objectives of this research were to analyze the level of awareness of ...
Subari, Nur Akhwa, Abdul Tharim, Asniza Hamimi, Che Ahmad, Asmalia   +2 more
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Full-Scale Experimental Investigation of Temperature Distribution and Smoke Flow in a Road Tunnel with a Novel Water Mist Fire Fighting System

Fire
This study presents a novel water mist fire fighting system that integrates water mist sprays and water mist curtains, designed to achieve simultaneous fire suppression, thermal insulation, and smoke control.
Shouzhong Feng, Deyuan Kan, Chao Guo
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Performance of the system of protection and fire fighting by hydrants: evaluation of system operating conditions / Performance of the system of protection and fire fighting by hydrants: evaluation of system operating conditions

, 2020
The protection by hydrants is essential in large buildings, it helps fight and control a start of a fire, not letting the fire spreading to other areas, thus the perfect system operation and proper use of the system equipment by building occupants ...
Sales, Samuel Senna de
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Зарубіжний досвід організації боротьби з шахрайством у страховій системі (Foreign experience of fighting fraud in insurance system) [PDF]

, 2016
Досліджено зарубіжний досвід організації боротьби з шахрайством у страховій системі. Виокремлено спільні риси та згруповано країни з подібною організацією.
Приказюк, Н. В. (Prykaziuk N. V.)
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