Results 241 to 250 of about 18,068,871 (282)

Errors in Figure 1 and Figure 4B

JAMA Network Open
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Structural mechanisms of pump assembly and drug transport in the AcrAB-TolC efflux system. [PDF]

Elife
Ge X, Gu Z, Wang J.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Structure-guided optimization of SLY1 expression and purification in Escherichia coli. [PDF]

Protein Sci
Jmii S, Bouard W, Rochas M, Dragon F, Cappadocia L.   +4 more
europepmc   +1 more source

PTEN restrains SHH medulloblastoma growth through cell autonomous and nonautonomous mechanisms. [PDF]

Elife
Lao Z, El Nagar S, Liang Y, Stephen D, Joyner AL.   +4 more
europepmc   +1 more source

RETRACTION: Novel Synthesis of Titanium Oxide Nanoparticles: Biological Activity and Acute Toxicity Study. [PDF]

Bioinorg Chem Appl
Applications BCA.
europepmc   +1 more source

The Ubiquitin Ligase Zinc Finger SWIM Domain-Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA-7 Axis. [PDF]

Glia
Lei J, Zhong S, Fan R, Shu X, Wang G, Guo J, Xue S, Zheng L, Ren A, Ji J, Yang B, Duan S, Wang Z, Guo X.   +13 more
europepmc   +1 more source

Loss of ZNRF3/RNF43 unleashes EGFR in cancer. [PDF]

Elife
Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y.   +18 more
europepmc   +1 more source

Correction to 'Enhancing Biodiversity-Function Relationships in Field Retting: Towards Key Microbial Indicators for Retting Control'. [PDF]

Environ Microbiol Rep
europepmc   +1 more source